How does this medication work? What will it do for me?
Gemfibrozil belongs to the class of medications known as fibrates. It is used to treat high cholesterol. It works by blocking the production of certain types of cholesterol, especially the type known as triglycerides.
Gemfibrozil is used in combination with a healthy diet and exercise to lower cholesterol levels in the blood. Reduction of cholesterol levels has been shown to reduce the risks associated with heart disease, such as heart attack.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
Store this medication at room temperature and keep it out of the reach of children.
What form(s) does this medication come in?
Lopid is no longer being manufactured for sale in Canada. For brands that may still be available, search under gemfibrozil. This article is being kept available for reference purposes only. If you are using this medication, speak with your doctor or pharmacist for information about your treatment options.
How should I use this medication?
The recommended adult dose of gemfibrozil is 600 mg twice daily, 30 minutes before the morning and evening meals. The maximum daily recommended dose of gemfibrozil is 1,500 mg.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take gemfibrozil if you:
- are allergic to gemfibrozil or any of the ingredients of the medication
- are allergic to fenofibrate or any other of the class of "fibrates" (e.g., clofibrate, bezafibrate)
- are breast-feeding
- are pregnant
- are taking an antidiabetes medication called repaglinide
- have a disorder known as type 1 hyperlipoproteinemia
- have severe liver disease, kidney disease, or gallbladder disease
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- nausea or vomiting
- skin rash
- stomach pain, gas, or heartburn
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- muscle pain
- unusual tiredness or weakness
Check with your doctor immediately if any of the following side effects occur:
- cough or hoarseness
- fever or chills
- lower back or side pain
- painful or difficult urination
- stomach pain (severe) with nausea and vomiting
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Liver function: People who have a history of liver disorders or jaundice should use gemfibrozil with caution. People taking gemfibrozil need to have their liver function tested regularly while they are on this medication.
Medical conditions: This medication may increase the risk for gallstones.
Pregnancy: Strict birth control methods must be used by women who may become pregnant while taking this medication. If you become pregnant despite using birth control, stop taking gemfibrozil contact your doctor. Women who are planning pregnancy should stop taking gemfibrozil several months before conception.
Breast-feeding: This medication should not be taken by breast-feeding mothers. A decision should be made whether to discontinue breast-feeding or discontinue gemfibrozil, taking into account the importance of the medication to the mother.
Children: The safety and effectiveness of this medication have not been established for children.
What other drugs could interact with this medication?
There may be an interaction between gemfibrozil and any of the following:
- "statin" medications (e.g., atorvastatin, fluvastatin, lovastatin, rosuvastatin, pravastatin, simvastatin)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.