How does this medication work? What will it do for me?
Desmopressin nasal solution belongs to 2 classes of medications: antidiuretics and antihemorrhagics. It can be used to treat central diabetes insipidus, a condition where the kidneys are unable to conserve water due to a lack of antidiuretic hormone (ADH). This condition causes frequent urination and thirst. It is also used to treat temporary increased thirst and urination that can occur after a head injury or certain types of brain surgery. For these uses, desmopressin nasal solution works by helping to reduce the amount of urine produced by the kidneys.
Desmopressin nasal solution may also be used to prevent bleeding for people with mild hemophilia A and mild von Willebrand's disease type I. Desmopressin nasal solution works by increasing certain components involved in blood clotting.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each mL contains desmopressin acetate 0.1 mg in an isotonic, aqueous solution containing 0.5% chlorobutanol as a preservative. Nonmedicinal incredients: sodium chloride and hydrochloric acid.
Each precompression metered dose spray pump contains desmopressin acetate 0.1 mg/mL in a buffered, isotonic, aqueous solution. Nonmedicinal ingredients: citric acid monohydrate, disodium hydrogen phosphate dehydrate, and benzalkonium chloride. Each depression delivers desmopressin acetate 10 µg.
How should I use this medication?
For diabetes insipidus: The usual recommended dose for adults is 10 µg to 40 µg daily. The usual recommended dose for children 3 months to 12 years of age is 5 µg to 30 µg daily. The dose may be given as a single dose or divided into 2 or 3 doses. The lowest effective dosage should be used. Do not drink any fluids for at least 1 hour before taking desmopressin and for 8 hours after using desmopressin.
For preventing bleeding: The usual recommended dose is one 150 µg spray in each nostril, or one 150 µg spray in one nostril for people who weigh less than 50 kg (110 lbs). If it is being used to prevent bleeding related to surgery, it is given 2 hours before surgery.
Follow the instructions in the package insert on how to use medication. This medication should not be sniffed or inhaled; it works by being absorbed through the nose. To ensure the best absorption of the medication, place a finger on the outside of the nostril you just sprayed to close it for 10 seconds. During this time, breathe through the unsprayed nostril or through your mouth. If you are unsure of how to administer the medication, talk to your pharmacist.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, administer it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
This medication comes in 2 forms: the spray and the rhinyle solution. Store the spray in an upright position at room temperature, protect it from light, and kept it out of the reach of children. Store the rhinyle solution in the refrigerator at 2°C to 8°C and keep it out of the reach of children.
This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Desmopressin nasal solution should not be used by anyone who:
- is allergic to desmopressin or to any of the ingredients of the medication
- is known to have decreased levels of sodium in their blood
- has habitual or psychogenic polydipsia (drinking excessive amounts water)
- has medical conditions that require treatment with diuretics (e.g., heart failure, high blood pressure)
- has moderately or severely reduced kidney function
- has primary nocturnal enuresis (bedwetting)
- has type IIB or platelet type (pseudo) von Willebrand's disease
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- flushing or redness of skin
- nasal discomfort
- stomach pain
- stuffy nose
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- swelling of the face or hands
- weight gain
Stop taking the medication and seek immediate medical attention if any of the following occur:
- symptoms of a severe allergic reaction (e.g., difficulty breathing, wheezing, hives)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Effectiveness: Desmopressin is not effective in controlling excessive urination caused by kidney disease, psychiatric conditions, low blood potassium, or high blood calcium.
Fluid and electrolyte balance: Fluid intake should be adjusted in order to reduce the possibility of water retention and low levels of sodium in the blood, especially in children and seniors. Talk to your doctor about how much fluid intake is appropriate for you or your child. People who are taking this medication will be monitored closely by their doctor. Stop taking this medication and get medical attention if you have symptoms of low sodium in the blood such as headache, nausea, or vomiting.
People who are dehydrated should wait until their water balance has been adequately restored before taking desmopressin.
Medical conditions: People with cystic fibrosis, heart failure, bleeding disorders, liver problems, or kidney problems should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Nasal problems: People who have nasal conditions such as inflammation of the nose, scarring, or swelling may not completely absorbed the medication. In these circumstances, the desmopressin nasal solution should not be used. Talk to your doctor about alternatives you can use.
Tolerance: There are reports of changes in response to the medication over time, usually when the medication has been used for longer than 6 months. Some people may experience decreased responsiveness, while others may experience a shortened duration of effect. If you notice this, contact your doctor.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor.
Breast-feeding: It is not known if desmopressin nasal solution passes into breast milk. If you are a breast-feeding mother and are taking desmopressin nasal solution, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children younger than 3 months of age.
What other drugs could interact with this medication?
There may be an interaction between desmopressin nasal solution and any of the following:
- diuretics ("water pills"; e.g., hydrochlorothiazide)
- nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, indomethacin, naproxen)
- selective serotonin reuptake inhibitors (SSRIs; e.g., fluoxetine, paroxetine, sertraline)
- tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.