How does this medication work? What will it do for me?

Testosterone belongs to a group of hormones called androgens (male hormones). Testosterone is responsible for the growth and development of the male sex organs as well as male sex characteristics such as chest hair, facial hair, pubic hair, voice changes, and muscle growth. A deficiency of testosterone can result in underdeveloped testes or erectile dysfunction (difficulty getting or keeping an erection).

Testosterone patches are used to treat testosterone deficiency. Testosterone patches should only be used if testosterone deficiency has been confirmed by symptoms and blood tests.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

Health Tool

Low Testosterone Treatment Options

Compare the treatment options for low testosterone so you can find one that is best for you.

What form(s) does this medication come in?

12.2 mg patch
Each patch contains a total of 12.2 mg testosterone and delivers 2.5 mg of testosterone per 24-hour period. Nonmedicinal ingredients: alcohol, glycerin, glycerol monooleate, methyl laureate, carbomer, purified water, and sodium hydroxide.

24.3 mg patch
Each patch contains a total of 24.3 mg of testosterone and delivers 5 mg testosterone per 24-hour period. Nonmedicinal ingredients: alcohol, glycerin, glycerol monooleate, methyl laureate, carbomer, purified water, and sodium hydroxide.

Health Tool

Talk to your doctor

Tips for getting the conversation started so you can start feeling like yourself again.

How should I use this medication?

The recommended adult starting dose is one 24.3 mg patch or two 12.2 mg patches (supplying 5 mg testosterone every 24 hours) applied to a clean, dry area of the skin of the back, stomach, upper arms, or thighs at approximately 10 pm nightly.

The patch has a protective backing that is removed to expose an adhesive surface. Apply the patch to a surface (as described above) that is not oily, damaged, hairy, or irritated. Make sure the edges of the patch stick well to the skin. Do not place the patch on the scrotum or on bony areas such as the hips or shoulders, on mucous-producing surfaces (e.g., inside of mouth or nose), or on damaged skin. Use a different site for each daily patch or patches. Do not use the same site twice in seven days.

When applied to clean, dry skin, the patches will remain in place during normal activities, including contact with water such as showering or swimming. Strenuous exercise or excessive perspiration may loosen the patches or cause them to fall off. If a patch falls off before noon, replace it with a fresh patch directly on the same site. If it falls off later in the day, do not replace it until the nighttime application (when a new site should be chosen). If a patch becomes loose, smooth it down again by rubbing over the edges of the patch. If you are not sure what to do after the patch falls off, contact your doctor or pharmacist for advice.

After use, remove the patch and fold it so that the adhesive side is on the outside. Place the used patch in the package that the new patch has been taken from, and discard it.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor.

Store patches at room temperature and protect from heat, light, and moisture. Keep patches and discarded patches out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Health Tool

Do you have low testosterone?

You may think your symptoms are a natural part of aging. Could low testosterone be to blame?

Who should NOT take this medication?

Do not use this mediction if you:

  • are allergic to testosterone or to any of the ingredients of the medication
  • are female (especially if you are pregnant or breast-feeding)
  • have, or are suspected to have, prostate or breast cancer

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • acne
  • aggressive behaviour
  • changes in sexual desire or drive
  • difficulty sleeping
  • dizziness
  • enlarged prostate
  • hair loss, thinning hair, or baldness
  • headache
  • mood changes
  • skin irritation where applied
  • weight gain

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • breast soreness or enlargement
  • depression
  • high blood pressure
  • problems with urination (change in frequency or colour, dribbling, pain or straining when urinating, weak urine stream, small urine amounts)
  • prolonged (more than 4 hours) or painful erections, or erections that happen too often
  • swelling of ankles and legs (for people with heart, liver, or kidney problems)
  • symptoms of liver problems, such as:
    • abdominal pain
    • dark urine
    • loss of appetite
    • nausea or vomiting
    • pale stools
    • yellow eyes or skin

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • symptoms of a serious allergic reaction, such as:
    • difficulty breathing
    • hives
    • rash
    • swollen face or throat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.


July 15, 2014

Health Canada has issued new restrictions concerning the use of testosterone products. To read the full Health Canada Advisory, visit Health Canada's web site at

Blood tests: Your doctor may recommend that you have regular blood tests while using this medication to check whether the medication is working and whether you are having certain side effects. Also, the use of testosterone may interfere with a number of laboratory tests. Tell all health professionals administering these tests that you are using this medication.

Diabetes: This medication may affect blood sugar levels. If you have diabetes, monitor your blood sugar carefully while using this medication.

Heart disease: If you have heart disease, your doctor should monitor your condition closely while you are using this medication. Report any swelling in the feet and lower legs to a doctor immediately.

Kidney or liver disease: If you have kidney or liver disease, your doctor should monitor your condition closely while you are using this medication. Report any swelling in the feet and lower legs to a doctor immediately.

Skin irritation: If you continue to experience skin irritation, your doctor may recommend that you apply a corticosteroid cream to the skin under the patch. Ointments are not recommended, as they may reduce testosterone absorption by the body. Talk to your doctor to determine a treatment that is best for you.

Sleep disorders: Treatment with testosterone may cause sleep apnea (interruption of breathing during sleep) and high blood pressure for some people, especially those with risk factors such as being overweight or having a chronic lung disease.

Sperm counts: This medication may reduce sperm counts if high doses are used, or if it is used for a prolonged period.

Pregnancy and breast-feeding: This medication should not be used by women, especially pregnant or breast-feeding women. It may have unwanted effects on the developing child, including masculinization of female children.

Seniors: Seniors may have an increased risk for prostate enlargement and should be evaluated for prostate cancer before starting testosterone replacement therapy.

What other drugs could interact with this medication?

There may be an interaction between testosterone patches and any of the following:

  • adrenocorticotropic hormone (ACTH)
  • corticosteroids (e.g., prednisone, dexamethasone)
  • cyclosporine
  • medications used to treat diabetes (e.g., insulin)
  • propranolol
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.