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Drug Info > I > ISDN
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DIN (Drug Identification Number)


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Brand Name


Common Name
isosorbide dinitrate

In this drug factsheet:

DIN (Drug Identification Number)

00441686 ISDN 10MG TABLET
00441694 ISDN 30MG TABLET

How does this medication work? What will it do for me?

Isosorbide dinitrate belongs to the class of medications called anti-anginals. It is used to prevent chest pain associated with angina. It works by relaxing blood vessels and increasing the blood and oxygen supply to the heart. Isosorbide dinitrate may reduce the number, length, and severity of angina attacks. Tolerance for exercise may be increased and the need for fast-acting nitroglycerin (tablets and spray) may be reduced.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

Oral tablets: The recommended dose of isosorbide oral tablets for long-term prevention of angina is 5 mg to 30 mg taken 4 times daily, leaving a period of time called the nitrate-free period (as discussed with your doctor) where the body is relatively free of the medication. For example, the medication may be taken at 8 am, 12 pm, 4 pm, and 8 pm. This schedule allows the medication to keep working effectively as it prevents your body from getting too used to its effects.

Sublingual tablets (tablets dissolve in 20 seconds under the tongue): Isosorbide sublingual (under the tongue) tablets are dissolved under the tongue to prevent an angina attack. Dissolve 1 or 2 tablets (5 mg to 10 mg) under the tongue, between the cheek and gum, or between the lip and gum every 2 to 4 hours. An extra dose of 5 mg to 10 mg may be taken before stressful situations that are likely to cause an angina attack. Do not eat drink, smoke, or chew tobacco while the tablet is dissolving. Talk to your doctor about the dose and nitrate-free period that are right for you.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by the doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is within 2 hours of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Sublingual tablets

5 mg
Each pink, round, flat-faced sublingual tablet engraved "5" on one side contains 5 mg of isosorbide dinitrate. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, 6 magnesium stearate, colloidal silicon dioxide, and D&C Red No. 30 Aluminum Lake.


10 mg
Each white, round, flat-faced, scored tablet engraved "10" on one side contains 10 mg of isosorbide dinitrate. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, and 6 magnesium stearate.

30 mg
Each white, round, flat-faced, scored tablet engraved "30" on one side contains 30 mg of isosorbide dinitrate. Nonmedicinal ingredients: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, 6 magnesium stearate, and colloidal silicon dioxide.

Who should NOT take this medication?

Do not take isosorbide dinitrate if you:

  • are allergic to isosorbide or any ingredients of the medication
  • have or are at risk for a heart condition known as cardiogenic shock (e.g., after a heart attack)
  • are taking a type of medication known as PDE-5 inhibitors, which are used for erectile dysfunction; e.g., sildenafil (Viagra®), tadalafil (Cialis®), vardenafil (Levitra®)



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