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Drug Info > A > Apo-Tramadol/Acet
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DIN (Drug Identification Number)


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Brand Name


Common Name
tramadol - acetaminophen

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

This combination product contains two medications: tramadol and acetaminophen. Tramadol belongs to a group of medications called opioid analgesics and acetaminophen belongs to a group of medications called analgesics. This combination medication is used to manage moderate to moderately severe pain in adults. It decreases pain by working on the central nervous system.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

The usual recommended dose of tramadol - acetaminophen is 1 or 2 tablets every 4 to 6 hours as needed for pain relief, up to a maximum of 8 tablets daily.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The tablets can be taken with or without food.

Do not stop taking this medication without talking with your doctor. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

It is important to take this medication exactly as prescribed by your doctor. If your doctor has told you to take this medication on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Each yellow, capsule-shaped, film-coated tablet, engraved "37.5-325" on one side and "APO" on the other, contains 37.5 mg of tramadol hydrochloride and 325 mg of acetaminophen. Nonmedicinal ingredients: microcrystalline cellulose, croscarmellose sodium, pregelatinized starch, povidone, stearic acid, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyethylene glycol, titanium dioxide, and yellow ferric oxide.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to tramadol, acetaminophen, or any ingredients of the medication
  • are allergic to other opioid medications (e.g., codeine, morphine)
  • are intoxicated with alcohol or other medications such as hypnotics, other opioids such as codeine or morphine, or psychotropic medications (i.e., medications for mental health conditions)
  • are taking or have taken MAO inhibitors (e.g., phenelzine, tranylcypromine, moclobemide) within the last 14 days



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