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Drug Info > J > Janumet
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DIN (Drug Identification Number)


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Brand Name

Janumet

Common Name
sitagliptin - metformin


In this drug factsheet:



DIN (Drug Identification Number)

02333856 JANUMET 50MG/500MG TABLET
02333864 JANUMET 50MG/850MG TABLET
02333872 JANUMET 50MG/1000MG TABLET

How does this medication work? What will it do for me?

This is a combination medication that contains 2 active ingredients: sitagliptin and metformin. They are used together, along with diet and exercise, to improve blood glucose (sugar) levels for adults with type 2 diabetes.

Sitagliptin belongs to the group of medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine. Incretin is a hormone that raises insulin levels when blood glucose is high and decreases the amount of glucose made by the body. Metformin belongs to the group of medications called biguanides. It works by reducing the amount of glucose made by the liver and by making it easier for glucose to enter into the tissues of the body.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The initial dose of sitagliptin - metformin is based on the dose of each medication that is currently being taken. Your doctor will determine the dose that is appropriate for you. This medication should be taken twice a day with meals. The maximum dose of sitagliptin is 100 mg per day and of metformin is 2,000 mg per day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does this medication come in?

50 mg/500 mg
Each light pink, capsule-shaped, film-coated tablet with "575" debossed on one side contains sitagliptin phosphate monohydrate 64.25 mg, and metformin hydrochloride equivalent to sitagliptin 50 mg as free base, and metformin hydrochloride 500 mg. Nonmedicinal ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate; film coating: black iron oxide, polyvinyl alcohol, polyethylene glycol, red iron oxide, talc, and titanium dioxide.

50 mg/850 mg
Each pink, capsule-shaped, film-coated tablet with "515" debossed on one side contains sitagliptin phosphate monohydrate 64.25 mg, and metformin hydrochloride equivalent to sitagliptin 50 mg as free base, and metformin hydrochloride 850 mg. Nonmedicinal ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate; film coating: black iron oxide, polyvinyl alcohol, polyethylene glycol, red iron oxide, talc, and titanium dioxide.

50 mg/1000 mg
Each red, capsule-shaped, film-coated tablet with "577" debossed on one side contains sitagliptin phosphate monohydrate 64.25 mg, and metformin hydrochloride equivalent to sitagliptin 50 mg as free base, and metformin hydrochloride 1,000 mg. Nonmedicinal ingredients: microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate; film coating: black iron oxide, polyvinyl alcohol, polyethylene glycol, red iron oxide, talc, and titanium dioxide.

Who should NOT take this medication?

Do not take sitagliptin - metformin if you:

  • are allergic to sitagliptin, metformin, or any ingredients of the medication
  • are breast-feeding
  • are pregnant or planning to become pregnant
  • are severely dehydrated
  • drink a lot of alcohol in a short term or on a regular basis
  • have cardiovascular collapse (sudden failure of blood circulation) or cardio-respiratory insufficiency (reduced oxygen supply to tissues)
  • have metabolic acidosis (including diabetic ketoacidosis) or a history of ketoacidosis or lactic acidosis (too much acid in the blood)
  • have or are recovering from a severe infection, trauma, or surgery
  • have poor blood glucose control or insulin-dependent (Type 1) diabetes
  • have reduced kidney function or kidney disease
  • have severely reduced liver function or liver disease


 

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