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Drug Info > M > Midodrine
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How does this medication work? What will it do for me?

Midodrine belongs to the class of medications known as vasopressors. It is used to relieve symptoms of low blood pressure (such as dizziness, lightheadedness, and fainting) for people with Parkinson's disease, diabetes, Bradbury-Eggleston syndrome, and Shy-Drager syndrome. It works by constricting the blood vessels, causing an increase in blood pressure.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

The usual recommended starting dose of midodrine for adults is 2.5 mg 3 times daily, taken with or without food. Midodrine may also be taken as frequently as 6 times a day, as long as the maximum daily dose of 30 mg is not exceeded. The last midodrine dose of the day should be taken at least 4 hours before bedtime. People with kidney disease may need lower doses.

Midodrine will be started under close medical supervision, usually in a hospital, clinic, or doctor's office. Both lying and sitting blood pressures should be measured every hour for 3 hours after the first and second doses of midodrine therapy and also when there is an increase in dose. Thereafter, blood pressures should be measured daily for the first month, and then twice weekly while on therapy. Midodrine should only be continued if the person appears to have improvement in their symptoms during the initial treatment.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue on with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light, and keep it away from heat and out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

2.5 mg
Each white, round tablet, scored and engraved "MID" over "2.5" on one side, contains 2.5 mg midodrine hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, and starch.

5 mg
Each orange, round tablet, scored and engraved "MID" over "5" on one side, contains 5 mg midodrine hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, starch, and FD&C Yellow No. 6 Aluminum Lake 40%.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to midodrine or to any of the ingredients of the medication
  • have a condition known as pheochromocytoma (a tumour of the adrenal gland)
  • have acute kidney disease
  • have an overactive thyroid
  • have difficulty passing urine
  • have persistent and excessive supine hypertension (high blood pressure when lying down)
  • have severe heart disease



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