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Drug Info > M > M.O.S-Sulfate
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DIN (Drug Identification Number)


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Brand Name


Common Name
morphine immediate release

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

Morphine belongs to the class of medications called narcotic analgesics (pain relievers). These pain relievers are also known as opioid analgesics. This medication relieves severe pain when less potent pain relievers are not effective. Opioids decrease pain by working on the brain to increase pain tolerance. Morphine immediate release works quickly. It will usually relieve pain within about 30 minutes.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

Doses of morphine vary widely and depend on an individual's circumstances.

After a certain dose of morphine has been taken for a period of time, the body often gets used to it and a higher dose of morphine is needed to relieve the pain. Generally, your doctor will try to find the dose of morphine that will give you acceptable pain relief without an unacceptable level of side effects. This helps to reduce the side effects of the medication and allows for the dose to be adjusted upwards if needed. Always check with your doctor if you feel your medication isn't working well anymore.

Over time, this medication may produce tolerance and physical dependence as your body becomes used to the medication. Tolerance occurs when a dose that used to provide acceptable pain relief is no longer effective, and higher doses are required to achieve the same level of pain relief. Physical dependence is a state where the body will go into withdrawal if the medication is stopped suddenly. If you have been taking morphine on a regular basis for a long period of time, talk to your doctor before stopping the medication, as withdrawal effects can occur.

Tolerance and physical dependence are not the same as addiction. Addiction is defined as a psychological need to use the medication for reasons other than pain relief. Although people may become addicted to this medication, it is most common for people who have had addictions to other substances in the past.

The liquid form of morphine may be mixed with a glass of fruit juice just before taking it to improve the taste.

If you are using a suppository, first remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum. If you find the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

5 mg
Each round, green tablet contains morphine sulfate, USP (pentahydrate) 5 mg. Nonmedicinal ingredients: cornstarch, croscarmellose sodium, D&C Yellow No. 10, FD&C Blue No. 1, isopropyl alcohol, lactose, magnesium stearate, microcrystalline cellulose, povidone, and talc.

10 mg
Each round, blue tablet contains morphine sulfate, USP (pentahydrate) 10 mg. Nonmedicinal ingredients: cornstarch, croscarmellose sodium, FD&C Blue No. 1, isopropyl alcohol, lactose, magnesium stearate, microcrystalline cellulose, povidone, and talc.

25 mg
Each round, pink tablet contains morphine sulfate, USP (pentahydrate) 25 mg. Nonmedicinal ingredients: cornstarch, croscarmellose sodium, FD&C Red No. 40, isopropyl alcohol, lactose, magnesium stearate, microcrystalline cellulose, povidone, and talc.

50 mg
Each round, orange tablet contains morphine sulfate, USP (pentahydrate) 50 mg. Nonmedicinal ingredients: cornstarch, croscarmellose sodium, FD&C Yellow No. 6, isopropyl alcohol, lactose, magnesium stearate, microcrystalline cellulose, povidone, and talc.

Who should NOT take this medication?

Morphine should not be taken by anyone who:

  • is allergic to morphine, other narcotic analgesics, or to any of the ingredients of the medication
  • is experiencing acute alcoholism or delirium tremens
  • is experiencing acute asthma or other obstructive airway disease
  • is experiencing acute respiratory depression
  • has a blockage of the gastrointestinal tract, particularly paralytic ileus
  • has a head injury, a brain tumour, or increased pressure inside the head or spinal cord
  • has a medication regimen (current or completed in the last 14 days) that includes MAO inhibitors such as phenelzine or tranylcypromine
  • has abnormal heart rhythms
  • has convulsive (seizure) disorders
  • has cor pulmonale
  • has severe depression of the central nervous system (i.e., sedation)
  • has suspected abdominal conditions which may require surgery



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