In this drug factsheet:DIN (Drug Identification Number)
|02236564 ||LOVENOX 300MG/3ML (MULTIPLE DOSE VIAL W/ PRESERVATIVE)|
|02236883 ||LOVENOX PREFILLED SYRINGES|
|02012472 ||LOVENOX 30MG/0.3ML PREFILLED SYRINGES|
How does this medication work? What will it do for me?
Enoxaparin is a type of low molecular weight heparin and belongs to the group of medications known as anticoagulants or antithrombotic agents. These medications reduce the clotting ability of the blood and can reduce the risk of harmful blood clots forming in blood vessels.
Enoxaparin is used to prevent and treat deep vein thrombosis (DVT), which is a condition that leads to the formation of blood clots in the blood vessels in the leg. These blood clots can sometimes travel to the lungs and block blood vessels there, resulting in a serious condition known as pulmonary embolism.
Enoxaparin may be used to prevent DVT in people who are bedridden due to serious illness (heart failure, severe chest infections, or respiratory failure), or after they have had certain types of surgery (such as hip or knee replacements; or abdominal, gynecological, urological, or colorectal surgery). Enoxaparin is also used to treat DVT with or without pulmonary embolism.
Enoxaparin is also used in combination with ASA to treat people who have unstable angina and non-Q-wave heart attacks (a type of heart attack that does not involve the full thickness of the heart wall).
This medication is also used to treat a particular type of heart attack called ST-segment elevation myocardial infarction (STEMI) and those who has Percutaneous Coronary Intervention (PCI) to open up the coronary arteries after a heart attack.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
How should I use this medication?
Enoxaparin is injected under the skin (subcutaneously, not intramuscularly). For acute-ST-segment elevation heart attacks, you will receive a single dose of enoxaparin injected into a vein. Subsequent doses are injected under the skin.
The recommended dose varies according to the individual and the condition being treated. If you are injecting the medication yourself, your doctor or health care professional will show you how to inject the medication properly. If you have any questions about how to use the medication, contact your doctor.
Steps to use the medication:
- Before injecting enoxaparin, wash your hands and clean the area of skin where you will inject with an alcohol swab. Do not rub the area to be injected. Only use the injection if the solution appears clear and colourless or pale yellow.
- Lie down and pinch a fold of skin (usually in the lower abdomen at least 5 cm away from your belly button and out towards the sides) between your finger and thumb. Choose a different place of the lower abdomen for each injection.
- Remove the needle cover by pulling it straight off the syringe.
- Push the entire needle vertically into the skin in one smooth quick motion, and then press down on the syringe plunger to inject the medication. Make sure you are holding the skin fold the entire time you are injecting the needle and pressing down on the syringe plunger.
- After giving the injection, remove the needle from your skin. A protective sleeve will automatically cover the needle. Use an alcohol swab to apply light pressure to the injection area for several seconds. Do not rub the site afterwards.
- Dispose of the syringe and needle safely (using a sharps container). Each syringe is for single use only.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using this medication without consulting your doctor.
It is important to use this medication exactly as prescribed by your doctor. If you miss an injection, take it as soon as possible and continue with your regular schedule. If it is almost time for your next injection, skip the missed dose and continue with your regular dosing schedule. Do not inject a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from heat, and keep it out of the reach of children. If you are using the multiple dose vial, do not store it for more than 28 days after the first use.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each multidose vial contains enoxaparin sodium 300 mg in 3 mL water for injection (concentration 10 mg/0.1 mL) and 1.5% (m/v) benzyl alcohol as a preservative.
30 mg/0.3 mL
Each syringe contains enoxaparin sodium 30 mg in 0.3 mL water for injection. The solution is preservative-free and intended for use as a single-dose injection.
40 mg/0.4 mL
Each syringe contains enoxaparin sodium 40 mg in 0.4 mL water for injection. The solution is preservative-free and intended for use as a single-dose injection.
60 mg/0.6 mL
Each syringe contains enoxaparin sodium 60 mg in 0.6 mL water for injection. The solution is preservative-free and intended for use as a single-dose injection.
80 mg/0.8 mL
Each syringe contains enoxaparin sodium 80 mg in 0.8 mL water for injection. The solution is preservative-free and intended for use as a single-dose injection.
100 mg/1 mL
Each syringe contains enoxaparin sodium 100 mg in 1 mL water for injection. The solution is preservative-free and intended for use as a single-dose injection.
The 60 mg/0.6 mL, 80 mg/0.8 mL, and the 100 mg/1 mL syringes are imprinted with a graduation scale of 1 mL with major increments of 0.1 mL and minor increments of 0.025 mL.
Each Lovenox® presentation has a solution pH of 5.5 to 7.5 with an approximate anti-factor Xa activity of 100 IU/1 mg of drug (with reference to the WHO First International Low Molecular Weight Heparin Reference Standard).
Who should NOT take this medication?
Do not use enoxaparin if you:
- are allergic to enoxaparin or any ingredients of the medication
- are allergic to other low molecular weight heparins or heparin
- are actively bleeding
- are receiving spinal or epidural anesthesia and will be needing multiple doses of enoxaparin
- currently have or have previously had a history of heparin-induced thrombocytopenia (decrease in the number of platelets) or a positive in vitro platelet-aggregation test while using enoxaparin
- have decreased platelets
- have a hemorrhagic cerebrovascular accident (bleeding into tissues of the brain)
- have acute or sub-acute bacterial endocarditis (heart infection)
- have an active gastric (stomach) or duodenal (intestinal) ulcer
- have eye problems due to diabetes or hemorrhage (bleeding)
- have injuries to and operations on the brain, spinal cord, eyes, or ears
- have major blood clotting disorders
- have other conditions or diseases involving an increased risk of bleeding
- have severe uncontrolled high blood pressure
- have kidney problems
- have liver problems
People who need repeated doses of enoxaparin should not receive anesthetics that are injected into the spine or epidural space.