Brand Name
222
Common Name
ASA - caffeine - codeine
In this drug factsheet:
DIN (Drug Identification Number)How does this medication work? What will it do for me?
This combination product contains three medications used for the relief of mild-to-moderate pain, fever, and inflammation. It may be used to treat conditions such as headaches, pain due to cold symptoms, toothache, pain of menstrual cramps, arthritis pain, and the pain caused by muscle strains and sprains.
Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
How should I use this medication?
The recommended adult dose varies according to need, but it is usually 1 or 2 tablets taken one to three times daily (every four to eight hours) as required. No more than 4 g of ASA (10 tablets) should be taken in any 24-hour period.
This medication should be taken exactly as prescribed by your doctor. This medication has the potential for being abused and for being habit forming and should be taken only as needed for pain unless otherwise directed by your doctor.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?
Each white tablet, engraved 222 contains ASA 375 mg, caffeine 15 mg (equivalent to 30 mg caffeine citrate) and codeine phosphate 8 mg. Nonmedicinal ingredients: cornstarch, disodium edetate, ethylcellulose, hydrogenated vegetable oil, microcrystalline cellulose, sodium carboxymethylcellulose and sodium lauryl sulfate.
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.
Who should NOT take this medication?
This medication should not be taken by anyone who:
- is allergic or sensitive to ASA, codeine, caffeine, or any of the ingredients of the medication
- has a history of blood clotting problems
- is receiving blood thinners such as warfarin
- has stomach ulcers or duodenal ulcers
- has severe anemia
- is allergic or sensitive to other anti-inflammatory medications
- is in the last three months of pregnancy or is nursing
- has pre-existing respiratory depression
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