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Drug Info > A > Aldactazide
Please enter the drug name or
DIN (Drug Identification Number)


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Brand Name


Common Name
spironolactone - hydrochlorothiazide

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

Spironolactone and hydrochlorothiazide both belong to the family of medications called diuretics (water pills). This combination medication is used to treat edema (fluid retention) that occurs with congestive heart failure and disorders of the kidney and liver. This combination of medications is also used to treat high blood pressure. It works by making the body lose excess water and salt.

One of the diuretics, spironolactone, is called a potassium-sparing diuretic and helps the body to retain potassium. Hydrochlorothiazide, on the other hand, causes potassium to be lost from the system. Potassium supplements are usually not required with this medication as the effects of the two diuretics balance each other out. This medication is normally used once the best strength of each of the ingredients is determined individually.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

The recommended adult doses range from 1 tablet (containing 25 mg spironolactone and 25 mg hydrochlorothiazide) daily to 4 tablets (containing 50 mg spironolactone and 50 mg hydrochlorothiazide) daily, taken in single or divided doses as prescribed by the doctor. Since this medication increases urine output, it is better to take it early in the day (i.e., with breakfast if you are taking a once-daily dose).

For children, this medication is based on body weight. It will be calculated by your child’s doctor to give 1.65 mg to 3.3 mg of spironolactone per each kilogram of body weight.

Spironolactone - hydrochlorothiazide may be taken with or without food, however, it should be taken the same way each day so that levels of the medication in the body remain steady. If stomach upset occurs, always take the medication with food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture and keep out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

25 mg/25 mg
Each light tan round biconvex film coated tablet, debossed "ALDACTAZIDE" and "25" on one side and "SEARLE" and "1011" on the other, with peppermint odor, contains spironolactone 25 mg and hydrochlorothiazide 25 mg. Nonmedicinal ingredients: calcium sulfate, cornstarch, magnesium stearate, peppermint flavoring, povidone, hypromellose, polyethylene glycol 400, carnauba wax, stearic acid, and opaspray K-1-7076.

50 mg/50 mg
Each light tan capsule-shaped film coated tablet debossed "ALDACTAZIDE" and "50" on one side and "SEARLE" and "1021" on the other, with peppermint odor, contains spironolactone 50 mg and hydrochlorothiazide 50 mg. Nonmedicinal ingredients: calcium sulfate, cornstarch, magnesium stearate, peppermint flavoring, povidone, hypromellose, polyethylene glycol 400, carnauba wax, stearic acid, and opaspray K-1-7076.

Who should NOT take this medication?

Do not take spironolactone - hydrochlorothiazide if you:

  • are allergic to spironolactone, hydrochlorothiazide, or any ingredients of the medication
  • are allergic to the class of medications called sulfonamides
  • are unable to produce urine
  • have Addison's disease
  • have high levels of potassium or calcium in your blood
  • have severely reduced liver function or progressive liver disease, except in certain circumstances
  • have significantly reduced kidney function
  • are using the medications eplerenone, heparin, or a low molecular weight heparin
  • are pregnant
  • are breast-feeding



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