amiloride - hydrochlorothiazide
In this drug factsheet:DIN (Drug Identification Number)
|00784400 ||APO-AMILZIDE 5MG/50MG TABLET|
How does this medication work? What will it do for me?
This is a combination product containing 2 medications (amiloride and hydrochlorothiazide) that belong to the class of medications called diuretics. This combination medication is used to decrease edema (fluid retention) that occurs with congestive heart failure and certain liver disorders. It is also used to lower high blood pressure.
This medication works by causing the body to lose excess water and salt. One of the diuretics, amiloride, called a potassium-sparing diuretic, does not cause potassium to be lost from the body, while the other, hydrochlorothiazide, does cause potassium to be lost from the body. When used together, the loss of potassium from the body is minimized.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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How should I use this medication?
The usual dose of amiloride – hydrochlorothiazide for high blood pressure or edema caused by heart disease is one or two tablets daily in one dose or in divided doses.
The usual dose of amiloride – hydrochlorothiazide for edema caused by liver disease is one tablet taken once daily.
If one dose is taken, it should be taken early in the day to avoid the need to visit the washroom during sleeping hours. This medication may be taken with or without food. Do not take more than four tablets daily.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each peach-coloured, diamond-shaped tablet, scored and identified with "APO" above the score and "5/50" below, contains 50 mg hydrochlorothiazide and 5 mg amiloride hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium bicarbonate, and sunset yellow aluminium lake 40%.
Who should NOT take this medication?
Do not use amiloride - hydrochloride if you:
- are allergic to hydrochlorothiazide or amiloride or any ingredients of the medication
- are allergic to sulfa drugs (e.g., sulfamethoxazole)
- have increased blood potassium levels (hyperkalemia)
- are taking potassium supplements or other potassium-sparing diuretics (e.g., triamterene or spironolactone)
- are unable to urinate
- have acute kidney failure
- have severe or progressive kidney disease
- have diabetic kidney disease