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Drug Info > O > OncoTICE
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DIN (Drug Identification Number)


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Brand Name


Common Name
bacillus Calmette-Guerin

In this drug factsheet:

DIN (Drug Identification Number)

02153513 ONCOTICE 800,000,000 U/VIAL

How does this medication work? What will it do for me?

Bacillus Calmette-Guérin (BCG) belongs to the group of cancer-fighting medications known as antineoplastics. BCG is thought to treat cancer in the bladder by stimulating the body's own defense system to attack the cancer cells.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

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How should I use this medication?

BCG is always administered under direct supervision of a doctor. It is added to a solution that is instilled into the bladder through a catheter (tube). Before the fluid is instilled into your bladder, you will be asked to empty your bladder completely. The solution containing BCG should be held in your bladder for 2 hours.

Your doctor may ask you to change positions about every 15 minutes in order for the medication to come in contact with as much of the inside of the bladder as possible. When an instillation of BCG is finished, you should be sitting down to empty your bladder. To prevent bladder problems, you will need to drink extra fluids for several hours after each treatment so that more urine is passed. Make sure to empty your bladder as frequently as possible.

Because BCG is a live bacteria, it can cause infection. It is therefore important to disinfect any urine passed in the first 6 hours after treatment with an equal amount of undiluted household bleach. Allow the urine to sit with the bleach for 15 minutes in the toilet before flushing it.

This procedure is usually repeated once a week for 6 weeks, with additional instillations occurring at the 8th and 12th week, and then once a month for a year.

Many things can affect the dose and schedule of medication that a person needs, such as body weight, other medical conditions, and other medications. Your doctor may decide on a schedule different than the one listed here.

It is important to use this medication exactly as prescribed by your doctor.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Each vial of freeze-dried preparation contains 1 to 8×108 CFU of TICE BCG which is equivalent to approximately 50 mg wet weight.

Who should NOT take this medication?

You should not use BCG if you:

  • are hypersensitive to one of the ingredients
  • are breast-feeding
  • have a reduced immune response (chemotherapy, radiation)
  • have a urinary tract infection, until the infection has cleared up
  • have an active tuberculosis infection
  • have current active infection
  • have hematuria or blood in urine
  • have tested positive for HIV
  • have had a recent biopsy or traumatic bladder catherization



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