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Drug Info > T > Tussionex
Please enter the drug name or
DIN (Drug Identification Number)


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Brand Name


Common Name
phenyltoloxamine - hydrocodone

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

This medication contains two medicinal ingredients: hydrocodone and phenyltoloxamine. Hydrocodone belongs to the class of medications called antitussives (cough suppressants). Phenyltoloxamine belongs to the class of medications called antihistamines.

These two ingredients work together for the treatment of exhausting or non-productive cough that is associated with cold or with upper respiratory allergic conditions. Relief from the symptoms of coughing usually lasts between 8 to 12 hours. Hydrocodone is a narcotic medication. This medication is normally prescribed only after non-narcotic medications have been found ineffective.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

Adults: The usual adult dose is 5 mL or 1 tablet every 8 to 12 hours. The maximum daily dose is 10 mL or 2 tablets.

Children (suspension): For children 1 to 5 years of age, the recommended dose is 2.5 mL every 12 hours, with a maximum daily dose of 5 mL. For children over 5 years, the recommended dose is 5 mL every 12 hours, with a maximum daily dose of 10 mL. This medication is not recommended for children under one year of age weighing less than 9 kg.

Shake this preparation well. Do not dilute with fluids or mix with other medication.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?


Each 5 mL of neutral-tasting, gold-coloured suspension contains hydrocodone 5 mg and phenyltoloxamine 10 mg. Nonmedicinal ingredients: alcohol 95%, FD&C Yellow No. 10, FD&C Yellow No. 6, glycerin, methylparaben, natural and artificial pineapple flavour, natural peach flavour, polacrilin potassium, propylene glycol, propylparaben, purified water, sorbitol, and xanthan gum.


Each light brown tablet, scored on one side and marked "0894" on the other, contains hydrocodone 5 mg and phenyltoloxamine 10 mg. Nonmedicinal ingredients: calcium phosphate dibasic, colloidal silicon dioxide, cornstarch, lactose, magnesium stearate, polacrilin potassium, and sucrose.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to phenyltoloxamine, hydrocodone, or any ingredients of the medication
  • have lesions inside the head causing increased pressure inside the head (intracranial pressure)
  • have pre-existing respiratory depression (breathing rate that is too slow)
  • have very high blood pressure
  • take MAO inhibitors such as phenelzine or tranylcypromine, or have taken them within the past 14 days



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