How does this medication work? What will it do for me?
Clobetasol is a topical (skin-applied) corticosteroid medication used to treat skin conditions that have not responded well to other corticosteroids, including severe psoriasis and eczematous dermatitis. The scalp lotion and shampoo are used to treat psoriasis and seborrheic dermatitis occurring on the scalp. Clobetasol works by reducing swelling, redness, and itching.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each bottle contains clobetasol propionate, 0.05%, USP, in a shampoo base. Nonmedicinal ingredients: shampoo base consisting of alcohol 10%, citric acid monohydrate, coco-betaine, polyquaternium-10, purified water, sodium citrate dihydrate, and sodium laureth sulfate.
Each gram of solution contains clobetasol propionate 0.5 mg. Nonmedicinal ingredients: alcohol, isopropyl myristate, sodium lauryl sulphate, and undecylenic acid. Each 59 mL bottle is accompanied by a spray pump which delivers approximately 0.16 mL with each spray.
Each gram of lotion contains clobetasol propionate USP 0.5 mg. Nonmedicinal ingredients: carbomer 1342, hydroxypropyl methylcellulose, mineral oil, polyoxyethylene glycol 300 isostearate, propylene glycol, purified water, and sodium hydroxide.
How should I use this medication?
Cream and ointment: Apply the medication sparingly to cover the affected area and gently rub it into the skin 2 or 3 times daily. The total dose applied should not be more than 50 g in a week. Use this medication with caution on lesions near the eye. Take care to prevent it from getting into the eye.
Lotion: Apply the lotion to the affected areas of skin 2 times daily and rub it in gently and completely. The total dose should not exceed 50 g (50 mL) in a week.
Scalp lotion: Apply the lotion 1 or 2 times daily to the affected areas of the scalp and rub in gently. The total dose should not exceed 50 mL in a week. Clobetasol scalp applications should not be used near an open flame.
Foam: Apply a thin layer of foam 2 times daily to the affected areas of the skin and rub in gently until the foam is absorbed. The foam is extremely flammable, so avoid fire, flames, sparks or smoking during and immediately after applying. The total dose applied should not exceed 50 g in a week.
Spray: Apply the solution 2 times daily to the affected areas of the skin and rub in gently. The total dose should not exceed 50 mL in a week.
Shampoo: A thin film of clobetasol shampoo should be applied directly to the affected area of the scalp once daily. The shampoo is applied to the lesions on dry scalp and rubbed in gently. Leave it on for 15 minutes before wetting the hair, lathering, and rinsing. The total dose applied should not be more than 50 mL in a week.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
When clobetasol 17 - propionate is used over extensive areas for prolonged periods or under dressings that don't breathe, it is possible that enough medication will absorb into the bloodstream to cause unwanted side effects. Therefore, it is advisable to use clobetasol 17 - propionate only for brief periods and to stop using it as soon as the problem clears.
This medication should not be used under dressings that don't breathe.
If you have not noticed improvement in your skin after a week, stop using the medication and contact your doctor.
It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Clobetasol 17 - propionate should not be used by or given to anyone who:
- is allergic to clobetasol propionate or any ingredients of the medication
- is allergic to other corticosteroids
- is under 12 months old
- has untreated infected bacterial, fungal, viral (herpes simplex, skin rash resulting from vaccination, chickenpox), or tuberculous skin lesions
Clobetasol 17 - propionate should not to be used to treat:
- acne vulgaris
- dermatitis around the mouth
- itching around the anus and genitals
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- burning, dryness, irritation, itching, or redness of skin (usually mild and temporary)
- eye pain (if certain products have been used near the eye)
- increased redness or scaling of skin sores (usually mild and temporary)
- skin colour changes
- skin infection
- skin rash (usually mild and temporary)
- softening and tearing of the skin
- thinning of skin with easy bruising
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- acne or oily skin
- burning and itching of skin
- lack of healing of skin condition
- numbness in fingers
- painful, red, or itchy pus-containing blisters in hair follicles
- unusual increase in hair growth, especially on the face
- visible lines or small blood vessels under the skin
- unusual loss of hair, especially on the scalp
- vision changes
The following side effects may occur if this medication is used improperly or for a long time:
Stop using the medication and seek immediate medical attention if any of the following occur:
- symptoms of a serious allergic reaction (e.g., difficulty breathing, dizziness, itching, rash, swelling)
- symptoms of high levels of corticosteroids in the blood stream (e.g., fatigue, increased thirst and urination, irritability, muscle weakness)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are using this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Inform all of your doctors that you are using topical (skin-applied) corticosteroids.
Absorption: When clobetasol 17 - propionate is used over extensive areas for prolonged periods and under dressings that don't breathe, it is possible that enough medication will absorb into the bloodstream to cause unwanted side effects. Therefore, it is advisable to use this medication for brief periods only and to stop using it as soon as the problem clears. Talk to your health care provider about how long you should use this medication.
Diabetes: When clobetasol 17-propionate is used over large areas of the body for prolonged periods or under dressings that don't breathe it is possible that enough medication will absorb into the bloodstream to affect blood sugar levels. If you have diabetes, your doctor should closely monitor your condition while you are using clobetasol 17-propionate, as it may affect blood sugar control (either increase or decrease blood sugar levels).
Eyes: Use this medication with care on lesions close to the eye. Getting the medication in the eye can increase the risk of increased eye pressure, glaucoma, or cataracts.
Infection: Contact your doctor if any infection is noticed around the area of application.
Medical treatment: Inform all health professionals involved in your care that you have been using a topical (skin-applied) corticosteroid.
Thinning of skin: Prolonged use of topical corticosteroid products may produce thinning of the skin and tissues under it. If you notice this effect, call your doctor.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using this medication, contact your doctor immediately.
Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are using clobetasol 17-propionate, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: Children are more likely to experience absorption of this medication into the bloodstream, resulting in unwanted effects. The safety and effectiveness of using this medication have not been established for children. Its use by children is not recommended.
Seniors: People over the age of 65 may need to use a smaller amount of this medication or use it less often.
What other drugs could interact with this medication?
There may be an interaction between clobetasol 17 - propionate and any of the following:
- aldesleukin other topical medications that contain corticosteroids
- topical medications that have irritating effects to the skin
If you are using any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.