How does this medication work? What will it do for me?
Goserelin is a medication that mimics the actions of gonadotropin-releasing hormone (GnRH or LHRH), a hormone that affects the release of sex hormones such as testosterone and estrogen. Goserelin is used to treat prostate cancer, breast cancer (if it develops before or around the time of menopause), and endometriosis (a painful condition caused by growth of extra tissue inside or outside the uterus). It is also used to help thin the lining of the uterus before surgery on the uterus.
Goserelin works by suppressing the production of testotersone and estrogen.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are receiving this medication, speak to your doctor. Do not stop receiving this medication without consulting your doctor.
What form(s) does this medication come in?
Each depot is supplied as a cylindrical rod containing goserelin acetate equivalent to 3.6 mg of goserelin. Each depot is presented in a sterile ready-to-use syringe with a 16 gauge needle for a single subcutaneous injection. Nonmedicinal ingredients: lactide-glycolide copolymer.
How should I use this medication?
The usual dose of goserelin is 3.6 mg injected under the skin in the abdominal area every 28 days. The injection is usually given by a health care professional.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.
It is important this medication be given exactly as recommended by your doctor. If you miss an appointment to receive goserelin, contact your doctor as soon as possible to reschedule your appointment.
This medication is stored at room temperature and should be protected from light and moisture.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Goserelin should not be used by anyone who:
- is allergic to goserelin or to any of the ingredients of the medication
- is breast-feeding
- is pregnant
- has undiagnosed abnormal vaginal bleeding
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- bone pain
- fast or irregular heartbeat
- joint pain
- mood changes, including anxiety or depression
- symptoms of heart failure (e.g., swelling of the feet or legs, shortness of breath, and fatigue)
- symptoms of increased blood sugar levels (e.g., increased thirst, blurred vision, frequent urination, fatigue, or weight loss)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- breathing problems
- chest pain
- pain, redness, swelling, and feeling of warmth in the calf
- severe allergic reaction (e.g., hives; difficulty breathing; wheezing; or swelling of the eyes, mouth, or lips)
- symptoms of a heart attack (e.g., sudden pain or discomfort in the chest, neck, jaw, shoulder, arms, or back; shortness of breath; nausea or vomiting; cool clammy skin; and anxiety or denial)
- symptoms of spinal cord compression (e.g., numbness or tingling sensations, loss of movement or weakness in arms or legs)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
September 8, 2011
Health Canada has issued new restrictions concerning the use of Zoladex® (goserelin). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Heart problems: People with heart disease or other heart problems such as heart failure or an abnormal heart rhythm should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Men and the heart: There may be an increased risk of heart-related events (e.g., heart attacks, stroke, heart-related death) in men being treated for prostate cancer with GnRH medications. Before you start treatment, tell your doctor if you have diabetes, heart disease, had a previous heart attack or stroke, or have cardiovascular risk factors (e.g., high blood pressure, smoking, or cholesterol). If you have any of these conditions, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Osteoporosis: Goserelin can cause bones to lose thickness. People at an increased risk for osteoporosis or who are taking medications that reduce bone thickness (e.g., prednisone or antiseizure medications), should discuss the risks and benefits of using goserelin with their doctor before starting treatment. Your doctor should monitor your bone thickness while you are taking this medication. Some people taking goserelin may be prescribed medications to reduce bone loss.
Pituitary tumour: Although very rare, pituitary gland tumours may develop, bleed, or collapse with goserelin treatment. If you experience severe headaches, vomiting, loss of eyesight or unconsciousness, get immediate medical attention.
Short-term worsening of medical condition: For some people, their medical condition may temporarily worsen during the first month of treatment with goserelin. If your medical condition appears to worsen, contact your doctor.
Spine problems: When people with cancer that has spread to their spine receive goserelin, spinal cord compression can occur. If you develop severe pain, numbness or weakness of the arms or legs, or difficulty urinating, contact your doctor immediately.
Pregnancy: Goserelin should not be used during pregnancy. A nonhormonal method of birth control (e.g., condom, diaphragm) should be used during treatment. If you become pregnant while using this medication, stop receiving goserelin and contact your doctor.
Breast-feeding: It is not known if goserelin passes into breast milk. Women should not breast-feed while receiving goserelin treatment due to risk of harm to the breast-feeding infant.
Children: The safety and effectiveness of using the medication have not been established for children.
What other drugs could interact with this medication?
There may be an interaction between goserelin and any of the following:
- estrogen and estrogen-containing birth control (in women)
- medications that may affect heart rhythm, such as:
- antiarrhythmic medications (e.g., amiodarone, sotalol, quinidine)
- antifungal medications (e.g., itraconazole, ketoconazole)
- certain antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
- certain antidepressants (e.g., amitriptyline, nortriptyline)
- certain asthma medications (e.g., salbutamol)
- narcotic painkillers (e.g., codeine, morphine, oxycodone)
- medications that promote loss of bone density (e.g., prednisone)
- testosterone and androgens (in men)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.