Medbroadcast


Brand Name
Coversyl

Common Name
perindopril

How does this medication work? What will it do for me?

Perindopril belongs to the class of medications called angiotensin converting enzyme (ACE) inhibitors. It is used to treat high blood pressure. It helps to control blood pressure by relaxing blood vessels. Perindopril may be used alone or in combination with other medications that reduce blood pressure, especially thiazide diuretics (water pills).

Perindopril is also used to treat mild to moderate congestive heart failure in combination with other medications such as diuretics and digoxin. It may also be used to decrease the risk of further cardiac (heart) events after a recent heart attack or for people with coronary artery disease.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.



How should I use this medication?

To treat high blood pressure, the usual dose of perindopril ranges from 4 mg to 8 mg daily taken in 1 dose or in 2 divided doses. Perindopril may be used alone or in combination with other medications to reduce blood pressure.

When used to treat congestive heart failure, the starting dose of perindopril is 2 mg. It may then be increased depending on the effect of the medication and side effects.

For best results, the tablets should be taken before a meal and on an empty stomach. Once-daily doses should be taken in the morning before breakfast. Seniors and people with kidney disease may require smaller doses.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by the doctor. If you miss a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.



What form(s) does this medication come in?

2 mg
Each white, round, film-coated, biconvex tablet contains perindopril erbumine 2 mg. Nonmedicinal ingredients: hydrophobic colloidal silica, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

4 mg
Each light green, rod shaped, film-coated tablet, engraved with a symbol on one face and scored on both edges contains perindopril erbumine 4 mg. Nonmedicinal ingredients: chlorophyllin (E141ii) aluminium lake, hydrophobic colloidal silica, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.

8 mg
Each green, round, film-coated, biconvex tablet, engraved with a symbol on one face and another symbol on the other contains perindopril erbumine 8 mg. Nonmedicinal ingredients: chlorophyllin (E141ii) aluminium lake, hydrophobic colloidal silica, lactose monohydrate, magnesium stearate, and microcrystalline cellulose.



Who should NOT take this medication?

Perindopril should not be taken by anyone who:

  • is allergic to perindopril or to any of the ingredients of the medication
  • is pregnant or is planning to become pregnant
  • has had angioedema (a serious allergic reaction which causes the area around the throat and tongue to swell) after taking any other ACE inhibitors (e.g., captopril, enalapril, ramipril)


What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • cough (dry, persistent)
  • diarrhea
  • dizziness
  • feeling weak
  • headache
  • loss of taste
  • metallic taste in mouth
  • muscle cramps
  • nausea
  • unusual tiredness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, cuts that won't stop bleeding)
  • signs of low blood pressure (e.g., dizziness, lightheadedness, fainting)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of too much potassium in the body (e.g., confusion, irregular heartbeat; nervousness; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; weakness or heaviness of legs)
  • skin rash, with or without itching, fever, or joint pain
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • fever and chills
  • signs of a serious allergic reaction (i.e., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.



Are there any other precautions or warnings for this medication?

HEALTH CANADA ADVISORY

February 4, 2014

Health Canada has issued new restrictions concerning the use of perindopril. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Angioedema: Although not common, angioedema (a serious allergic reaction that causes the area around the throat and tongue to swell) may occur with ACE inhibitors, including perindopril. If you experience swelling of the face, tongue, or glottis, stop taking perindopril at once and seek immediate medical attention. People who have had angioedema caused by other substances may be at increased risk of angioedema while taking an ACE inhibitor such as perindopril.

Diabetes: Perindopril may affect blood sugar control. People with diabetes should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. You may need to test your blood sugar more often when you first start taking this medication.

Fluid and electrolyte balance: Increases in blood levels of potassium may occur as a result of taking perindopril. This rarely causes problems, but your doctor will probably want to monitor your potassium levels regularly with blood tests.

Kidney function: Changes in kidney function have been seen in certain people. The use of diuretics (water pills) may further increase the risk of kidney problems for those already at risk for this. People with kidney disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver disease: People with liver disease should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Low blood pressure: Occasionally, blood pressure drops too low after perindopril is taken. This usually happens after the first or second dose or when the dose is increased. It is more likely to occur for those who take water pills, have a salt-restricted diet, are on dialysis, are suffering from diarrhea or vomiting, or have been sweating excessively and not taking in enough fluids. If low blood pressure causes you to faint or feel lightheaded, contact your doctor.

Pregnancy: Perindopril must not be taken by pregnant women. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking perindopril, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of the use of perindopril by children have not been established. Its use by this age group is not recommended.



What other drugs could interact with this medication?

There may be an interaction between perindopril and any of the following:

  • antidiabetes medications (e.g., insulin, metformin, glyburide)
  • cyclosporine
  • diuretics (e.g., spironolactone, amiloride, furosemide, hydrochlorothiazide)
  • gentamicin
  • heparin
  • lithium
  • medications that lower blood pressure (e.g., beta-blockers, amitriptyline, anesthetics, haloperidol, olanzapine)
  • nonsteroidal anti-inflammatory medications (NSAIDs; e.g., indomethacin, naproxen)
  • other blood pressure medications known as angiotensin II receptor blockers (e.g., candesartan, losartan)
  • potassium supplements
  • salt substitutes containing potassium

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.




The contents of this site are for informational purposes only and are meant to be discussed with your physician or other qualified health care professional before being acted on. Never disregard any advice given to you by your doctor or other qualified health care professional. Always seek the advice of a physician or other licensed health care professional regarding any questions you have about your medical condition(s) and treatment(s). This site is not a substitute for medical advice.
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