progesterone (for hormone replacement therapy)
In this drug factsheet:DIN (Drug Identification Number)
|02166704 ||PROMETRIUM 100MG CAPSULE|
How does this medication work? What will it do for me?
Progesterone belongs to the class of medications called progestins. It is used in combination with postmenopausal estrogen replacement therapy (ERT) to prevent the estrogen from thickening the lining of the uterus (a condition known as endometrial hyperplasia). This significantly reduces the risk of endometrial cancer. This medication is used for women who have a uterus.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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How should I use this medication?
The recommended dose of progesterone is 200 mg daily taken at bedtime for the last 14 days of estrogen treatment per cycle. Women who take high doses of estrogen should receive a progesterone dose of 300 mg per day. If the dose is 300 mg daily, 200 mg should be taken at bedtime and 100 mg should be taken 2 hours after breakfast for the last 12 to 14 days of estrogen treatment per cycle.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you are using 200 mg daily and miss a dose of this medication at bedtime (i.e., 2 of the 100 mg capsules), take an extra dose of 100 mg (1 capsule) the following morning and continue taking the rest of the capsules as prescribed by your doctor. If you are taking 300 mg daily and miss a dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each capsule contains micronized progesterone 100 mg. Nonmedicinal ingredients: sunflower oil, gelatin, glycerin, soya lecithin, and titanium dioxide.
Who should NOT take this medication?
Do not take progesterone if you:
- are allergic to progesterone, peanuts (the capsules contain peanut oil), soya, or any ingredients of this medication
- are or may be pregnant
- have a history of blood clots (e.g., pulmonary embolism, deep vein thrombosis) or blood clotting disorders
- have a tumour dependent on progesterone or estrogen for growth (e.g., breast or endometrial cancer)
- have active liver disease
- have classical migraines
- have endometrial hyperplasia (overgrowth of the lining of the uterus)
- have had a stroke, heart attack, or heart disease
- have partial or complete loss of vision due to blood vessel disease of the eye
- have unexplained abnormal vaginal bleeding