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Drug Info > N > Neo-Medrol Acne Lotion
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DIN (Drug Identification Number)


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Brand Name

Neo-Medrol Acne Lotion

Common Name
neomycin - methylprednisolone topical (for acne)

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

This is a combination medication that contains two active ingredients: neomycin and methylprednisolone. Neomycin is an antibiotic that helps kill the bacteria that may cause or aggravate acne. Methylprednisolone is an anti-inflammatory that helps to reduce the redness and swelling associated with acne. This medication is used to control acne in adolescents and young adults and is sometimes used to treat seborrheic dermatitis and acne rosacea.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

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How should I use this medication?

Carefully clean the affected skin to minimize the possibility of causing additional infection. Apply the lotion sparingly to the affected areas once or twice daily. Take care to avoid contact with the eyes. Some people may need to reduce the initial frequency of application because of the drying effects of the medication. They may find that using the medication once every other day will sufficiently control their symptoms.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Each mL contains methylprednisolone acetate 2.5 mg, neomycin sulfate 2.5 mg, aluminum chlorhydroxide complex 100 mg, and colloidal sulfur 50 mg. Nonmedicinal ingredients: butylparaben, cetyl palmitate, lexemul ar, methylcellulose, methylparaben, perfume oil, polyethylene glycol, polysorbate 80, polysorbate 85, and propylene glycol.

Who should NOT take this medication?

Neomycin - methylprednisolone topical should not be used by anyone who:

  • is allergic to neomycin, to methylprednisolone, or to any of the ingredients of the medication
  • has chickenpox
  • has herpes simplex
  • has other skin infections that do not respond to neomycin
  • has tuberculosis of the skin
  • has vaccinia



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