In this drug factsheet:DIN (Drug Identification Number)
|02377233 ||ELIQUIS 2.5MG TABLET|
|02397714 ||ELIQUIS 5 MG TABLET|
How does this medication work? What will it do for me?
Apixaban belongs to the group of medications called anticoagulants. Anticoagulants prevent harmful blood clots from forming in the blood vessels. They do this by reducing the ability of the blood to clot.
Apixaban is used to prevent blood clots for people who have had total hip replacement or knee replacement surgery. It may also be used to prevent stroke or blood clots in people with atrial fibrillation (a type of abnormal heart rhythm).
Apixaban is also used to treat and prevent clots from forming in the legs (deep vein thrombosis[DVT])or in the lungs (pulmonary embolism).
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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How should I use this medication?
For knee replacement surgery or hip replacement surgery, the usual dose of apixaban is 2.5 mg twice daily (once in the morning and once in the evening, about 12 hours apart). The first dose is usually taken 12 to 24 hours after surgery. For hip surgery, treatment will usually continue for up to 38 days. For knee surgery, treatment will usually continue for up to 14 days.
For stroke and clot prevention in people with atrial fibrillation, the usual dose is 5 mg twice daily (once in the morning and once in the evening, about 12 hours apart).
To treat DVT or pulmonary embolism, the recommended dose is 10 mg taken twice a day for 7 days. The dose is then reduced to 5 mg taken twice a day. Treatment is continued for at least 6 months.
After treating the blood clot, the recommended dose to continue to prevent DVT or pulmonary embolism is 2.5 mg taken twice a day. For a maximum effect from this medication, apixaban should be taken regularly, approximately 12 hours separating each dose.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Apixaban may be taken with food or on an empty stomach.
It is important to take this medication exactly as prescribed by your doctor.
If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each yellow, round tablet, with "893" marked on one side and "2 ½" on the other side, contains 2.5 mg apixaban. Nonmedicinal ingredients: tablet core: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate; film coat: hypromellose, lactose monohydrate, titanium dioxide, triacetin, and yellow iron oxide.
Each pink, oval tablet, with "894" marked on one side and "5" on the other side, contains 5 mg apixaban. Nonmedicinal ingredients: tablet core: anhydrous lactose, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate; film coat: hypromellose, lactose monohydrate, titanium dioxide, triacetin, and red iron oxide.
Who should NOT take this medication?
Do not take this medication if you:
- are allergic to apixaban or any ingredients of the medication
- are bleeding actively (e.g., bleeding stomach ulcer) or have a medical condition that increases your risk of bleeding
- are taking certain medications such as ketoconazole, itraconazole, voriconazole, posaconazole, or ritonavir
- are taking other anticoagulants such as enoxaparin, dalteparin, fondaparinux, warfarin, dabigatran, or heparin (unless your doctor has decided to switch you to apixaban)
- have a body lesion at risk of bleeding, including bleeding in the brain within the last 6 months
- have liver disease associated with an increased risk of bleeding