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Drug Info > P > Prolopa
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DIN (Drug Identification Number)


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Brand Name


Common Name
levodopa - benserazide

In this drug factsheet:

DIN (Drug Identification Number)

00522597 PROLOPA 50-12.5 CAPSULE
00386464 PROLOPA 100-25 CAPSULE
00386472 PROLOPA 200-50 CAPSULE

How does this medication work? What will it do for me?

This combination product contains 2 ingredients: levodopa and benserazide. Together, they are used to treat Parkinson's disease.

Parkinson's disease is an illness that develops when the brain is not receiving enough of the chemical dopamine to allow the body to move normally. Levodopa helps to control the symptoms of Parkinson's disease by correcting the chemical imbalance in the brain that produces symptoms. Levodopa can be used alone, but adding benserazide lowers the amount of levodopa that is required, and may reduce some of the side effects such as nausea and vomiting that are associated with levodopa. Although levodopa helps relieve symptoms of Parkinson's disease, it does not slow down the progression of the disease.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

Treatment with levodopa - benserazide should be started at low doses and increased gradually to reduce the risk of side effects while gaining maximum benefit from the medication.

For someone who has never taken levodopa, the recommended starting dose is one capsule of levodopa 100 mg - benserazide 25 mg once or twice a day. Your doctor will usually increase the dose by one capsule every third or fourth day until the best effect occurs without side effects.

When the dose gets higher, your doctor may increase the dose at 2 to 4 week intervals. This dose should be divided so that the medication is taken at least 4 times a day with, or immediately after, meals.

If you have been taking another form of levodopa, your doctor will determine your starting dose, based on the amount of levodopa you have been taking most recently. The dose of levodopa in levodopa - benserazide is usually quite a bit lower than your original dose. The benserazide helps the levodopa to get to where it is needed, so less levodopa is needed.

Most people find the best dose  is 4 to 8 capsules of levodopa 100 mg - benserazide 25 mg daily (divided into 4 to 6 doses).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the one above, do not change the way that you are taking the medication without consulting your doctor.

When first starting the medication, it may be taken with meals or a snack to reduce stomach upset. Protein prevents levodopa - benserazide from being absorbed. Take this medication with a small snack, such as crackers or biscuits to help prevent upset stomach.

Swallow the capsules whole and do not open them. Do not dissolve them in liquid.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

50 mg/12.5 mg
Each light-grey and blue capsule, marked with "ROCHE" in black ink on both body and cap, contains levodopa 50 mg and benserazide base 12.5 mg in the form of benserazide hydrochloride. Nonmedicinal ingredients: gelatin, indigotine, iron oxide, magnesium stearate, mannitol, microcrystalline cellulose, povidone, talc, and titanium dioxide.

100 mg/25 mg
Each blue and pale-pink capsule, marked with "ROCHE" in black ink on both body and cap, contains levodopa 100 mg and benserazide base 25 mg in the form of benserazide hydrochloride. Nonmedicinal ingredients: gelatin, indigotine, iron oxide, magnesium stearate, microcrystalline cellulose, povidone, talc, and titanium dioxide.

200 mg/50 mg
Each blue and caramel-coloured capsule, marked with "ROCHE" in black ink on both body and cap contains levodopa 200 mg and benserazide base 50 mg in the form of benserazide hydrochloride. Nonmedicinal ingredients: gelatin, indigotine, iron oxide, magnesium stearate, microcrystalline cellulose, povidone, talc, and titanium dioxide.

Who should NOT take this medication?

Do not use this medication if you:

  • are allergic to levodopa, benserazide, or any ingredients of the medication
  • are under 25 years of age
  • are pregnant or may become pregnant
  • cannot take sympathomimetic amines (e.g., epinephrine)
  • have a psychiatric disorder
  • have active heart disease, blood-related conditions, endocrine disease, liver disease, lung disease, or kidney disease
  • have narrow-angle glaucoma
  • have taken MAO inhibitors (e.g., moclobemide, phenelzine, tranylcypromine) within 2 weeks of taking levodopa - benserazide



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