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Drug Info > P > Prolia
Please enter the drug name or
DIN (Drug Identification Number)


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Brand Name

Prolia

Common Name
denosumab


In this drug factsheet:



DIN (Drug Identification Number)

02343541 PROLIA 60MG/ML SOLUTION (PREFILLED SYRINGE)

How does this medication work? What will it do for me?

Denosumab belongs to a family of medications known as monoclonal antibodies. Specifically, it is a RANK ligand inhibitor. It is used to treat osteoporosis for postmenopausal women with a high risk of fracture or who have not tolerated or responded to other osteoporosis medications. It is also used to increase bone mass in men who have osteoporosis and are at high risk of having a fracture, have a history of osteoporotic fracture or have not tolerated or responded to other osteoporosis medications.

Denosumab works by reducing the amount of bone your body breaks down, making your bones less likely to break.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

Learn more about related conditions:

These conditions are related to the conditions the drug is approved to treat. The drug may not be approved to treat all of the conditions listed here.

How should I use this medication?

When used to treat osteoporosis, the recommended dose of denosumab is 60 mg injected once every 6 months. This medication is injected subcutaneously (under the skin) of the upper arm, upper thigh, or abdomen. Your doctor may show you how to give yourself the injections, or a health care professional will inject the medication for you.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that this medication be used exactly as recommended by your doctor. If you miss an appointment to receive denosumab, contact your doctor as soon as possible to reschedule your appointment. If you are injecting this medication yourself and miss a dose, use it as soon as you remember. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

This medication is stored in the refrigerator, protected from light and temperatures above 25°C. Do not allow this medication to freeze. Keep it out of the reach of children. When removed from ther refrigerator, it can also be stored at room temperature for 30 days. It should be allowed to reach room temperature before injecting.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does this medication come in?

Each 1 mL single use prefilled syringe of sterile, preservative-free, clear, colourless to slightly yellow solution contains 60 mg denosumab. Nonmedicinal ingredients: sorbitol, acetate, polysorbate 20, water for injection (USP), and sodium hydroxide to adjust for pH.

Who should NOT take this medication?

Do not use denosumab if you:

  • are allergic to denosumab or any ingredients of the medication
  • have low blood calcium levels
  • are pregnant or breast feeding


 

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