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Drug Info > X > Xarelto
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Brand Name
Xarelto

Common Name
rivaroxaban


In this drug factsheet:



What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • bleeding
  • bruising
  • constipation
  • decreased energy
  • diarrhea
  • fluid buildup in legs, ankles
  • headache
  • increased menstrual bleeding
  • nausea
  • stomach ache
  • vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • bleeding or oozing from the surgical wound
  • confusion
  • decreased urine production
  • fast heartbeat
  • itchy skin or skin rash
  • signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of bleeding (e.g., bloody nose that lasts for more than 5 minutes, blood in urine, coughing blood, cuts that don't stop bleeding, gums that bleed for longer than 5 minutes when brushing teeth, bleeding into the rectum or from hemorrhoids, excessive menstrual bleeding)
  • signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of low blood pressure (e.g., dizziness, lightheadedness, fainting)
  • stiff, sore, hot, or painful joints
  • symptoms of unidentified bleeding (e.g., weakness, paleness, dizziness, headache, unexplained swelling)
  • unexpected bruising or bleeding after surgery

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • signs of a serious allergic reaction (i.e., hives, difficulty breathing, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Increased bleeding risk: If you have conditions that are associated with an increased risk of bleeding (e.g., bleeding problems; uncontrolled very high blood pressure; a problem with the blood vessels in the back of the eye called retinopathy; current or past ulcer of the stomach or intestines; or recent stroke, recent surgery of the brain, spinal column, or eye), discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney disease: If you have kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Lactose: This medication contains lactose. People with certain rare problems associated with lactose or galactose intolerance (e.g., Lapp lactase deficiency, glucose-galactose malabsorption) should not take this medication.

Liver disease: If you have liver disease or decreased liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Spinal or epidural injection or catheters: If you have a spinal or epidural catheter, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Surgery: Inform all health care professionals involved in your care that you are taking rivaroxaban. Rivaroxaban may need to be stopped temporarily before dental or surgical procedures to reduce your risk of bleeding heavily during or after the procedure.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Rivaroxaban may pass into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. This medication is not recommended to be taken while breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children less than 18 years of age.

Seniors: The side effects of this medication may be more noticeable in seniors. People who are over 65 years old should discuss with their doctor how this medication may affect them and whether any special monitoring is needed.





What other drugs could interact with this medication?

There may be an interaction between rivaroxaban and any of the following:

  • abcixamab
  • acetylsalicylic acid
  • alteplase
  • amiodarone
  • anagrelide
  • apixaban
  • argatroban
  • atorvastatin
  • azole antifungal medications (e.g., ketoconazole, itraconazole, voriconazole)
  • barbiturates (e.g., pentobarbital, phenobarbital)
  • bosentan
  • carbamazepine
  • carvedilol
  • clopidogrel
  • cobicistat
  • conivaptan
  • corticosteroids (e.g., dexamethasone, hydrocortisone, methylprednisone, prednisone)
  • cyclosporine
  • dabigatran
  • dasatinib
  • deferasirox
  • diltiazem
  • dipyridamole
  • doxorubicin
  • dronedarone
  • enzalutamide
  • fondaparinux
  • garlic
  • ginger
  • ginkgo biloba
  • ginseng
  • grapefruit juice
  • heparin and low-molecular weight heparins (e.g., enoxaparin, dalteparin)
  • lapatinib
  • macrolides (e.g., erythromycin, clarithromycin)
  • mefloquine
  • nefazodone
  • nicardipine
  • nilotinib
  • non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz)
  • nonsteroidal anti-inflammatory medications (NSAIDs; e.g., diclofenac, ibuprofen, naproxen)
  • oxcarbazepine
  • phenytoin
  • HIV protease inhibitors (e.g., darunavir, indinavir, ritonavir)
  • omega-3-fatty acids
  • prasugrel
  • prazosin
  • primidone
  • progesterone
  • propranolol
  • quinidine
  • quinine
  • red clover
  • rifabutin
  • rifampin
  • rifampicin
  • SSRIs (e.g., citalopram, escitalopram, fluoxetine, paroxetine)
  • St. John's wort
  • sunitinib
  • tacrolimus
  • tamoxifen
  • teleprevir
  • trazodone
  • ticagrelor
  • ticlopidine
  • tirofiban
  • tocilizumab
  • ulipristal
  • vandetanib
  • vemurafenib
  • verapamil
  • vinblastine
  • vitamin E
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.





 

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