In this drug factsheet:
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses.
Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- stomach pain
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abdominal tenderness
- severe abdominal or stomach cramps or pain
- severe watery or bloody diarrhea
- signs of bleeding (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
- signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- skin rash, redness, and itching
- sore throat
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the mouth, tongue, lips, or throat)
- symptoms of a severe skin rash (e.g., blistering, peeling skin, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Antibiotic-related diarrhea: As with other antibiotics, clindamycin can cause a severe form of diarrhea associated with a condition known as pseudomembranous colitis. If you develop severe diarrhea while taking (or within a few weeks of taking) this medication, contact your doctor as soon as possible.
Liver disease: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Overgrowth of organisms: The use of antibiotics occasionally results in the overgrowth of organisms that the antibiotics don't kill, such as other bacteria or fungi. This can cause other infections, such as yeast infections, to develop. If you experience new symptoms while taking clindamycin, contact your doctor.
Gastrointestinal problems: Severe diarrhea associated with this antibiotic may be mistaken for symptoms of chronic gastrointestinal conditions. If you have colitis, inflammatory bowel disease, or Crohn's disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Pregnancy: The safety of this medication for use during pregnancy has not been established. This medication should not be used unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking clindamycin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Seniors: Seniors may be more likely to experience antibiotic-related diarrhea associated with clindamycin.
What other drugs could interact with this medication?
There may be an interaction between clindamycin and any of the following:
- BCG vaccine
- non-depolarizing muscle relaxants (e.g., atracurium, doxacurium, mivacurium, pancuronium)
- sodium picosulfate
- typhoid vaccine
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.