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Drug Info > L > Lyrica
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Brand Name
Lyrica

Common Name
pregabalin


In this drug factsheet:



What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • dizziness
  • drowsiness or sleepiness
  • dry mouth
  • feeling of euphoria (extreme well-being)
  • forgetfulness
  • gas
  • lack of energy
  • muscle weakness
  • nervousness
  • trouble concentrating
  • weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • balance problems
  • blurred vision
  • cough
  • extreme fatigue or tiredness
  • flu-like symptoms (e.g., fever, headache, cough)
  • hallucinations
  • increase in blood pressurelack of coordination
  • skin inflammation or redness
  • signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
  • swelling of the extremities (hands and feet)
  • thoughts of harming yourself, suicide
  • twitching
  • unexplained muscle pain, tenderness, or weakness (especially if accompanied by fever or a general feeling of being unwell)
  • urinary incontinence (inability to control or hold urine)
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • symptoms of an allergic reaction (shortness of breath or difficulty breathing; hives; swelling of the eyes, mouth, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergic reaction: Some people have developed a serious allergic reaction called angioedema to this medication. Symptoms include swelling of the face, mouth (lips, gums, tongue), neck, throat, and upper airway. If these occur, seek immediate medical attention.

Central nervous system (CNS) depressants: Taking CNS depressants such as opiates (e.g., morphine, codeine) and benzodiazepines (e.g., diazepam, lorazepam) while taking pregabalin could result in excessive sleepiness or drowsiness and even coma. Talk to your doctor if you are taking these medications.

Drowsiness/reduced alertness: Pregabalin may cause dizziness and drowsiness. Do not engage in activities requiring mental alertness, such as driving or operating machinery, until you know how this medication affects you.

Drinking alcohol while you are taking pregabalin may make these effects more pronounced. It is strongly recommended that you avoid drinking alcohol while you are taking pregabalin.

Heart problems: Pregabalin may cause fluid to build up in the body. If the fluid accumulates around the lungs or heart, symptoms of heart failure may become worse. If you have heart failure or other heart problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any signs of heart problems getting worse, such as difficulty breathing, rapid weight gain or chest pain to your doctor immediately.

Kidney function: Pregabalin is primarily eliminated from the body by the kidneys. Kidney disease or decreased kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregabalin may reduce kidney function and can cause kidney failure. If you notice any signs of your kidneys not working well, such as decreased amounts of urine being produced, swelling of the legs and ankles, difficulty urinating, or an increased need to urinate at night, contact your doctor as soon as possible.

Male fertility: Animal studies have shown the use of pregabalin to be associated with decreased fertility, sperm abnormalities, and birth defects. It is not known if these effects would happen in people. If you plan to father a child, discuss using this medication with your doctor first.

Muscle pain: If you experience muscle pain, tenderness, or weakness with or without fever, contact your doctor immediately.

Skin problems: Pregabalin may cause skin ulcers or sores. Pay extra attention to your skin while taking this medication, especially if you have diabetes. If you notice any new skin sores or skin problems let your doctor know.

Stopping this medication: Stopping pregabalin suddenly may result in withdrawal symptoms such as insomnia, nausea, headache, diarrhea and seizures. If it is necessary to stop taking this medication, talk to your doctor about the best way to reduce your dose before stopping your medication.

Suicidal behaviour: People taking this medication may feel that they may want to hurt themselves or others. These symptoms may occur within several weeks after starting this medication. If you experience these side effects or notice them in a family member who is taking this medication, contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking this medication.

Vision disturbances: Pregabalin may cause disturbances in your vision such as blurred vision, double vision, and vision loss. Report any changes in your vision to your doctor immediately.

Weight gain: Pregabalin may cause weight gain and swelling of the extremities. Report any significant weight gain or any swelling of the legs, arms, or other areas of the body to your doctor.

Pregnancy: Information about the safety and effectiveness of using pregabalin during pregnancy is limited. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if pregabalin passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of using this medication have not been established for children and adolescents less than 18 years of age.

Seniors: The effectiveness of the kidneys in removing  pregabalin from the body tends to decrease with age. Seniors may need lower doses of this medication to reduce the possibilty for side effects.



What other drugs could interact with this medication?

There may be an interaction between pregabalin and any of the following:

  • alcohol
  • antihistamines (e.g., diphenhydramine, doxylamine, hydroxyzine)
  • anti-psychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
  • azelastine
  • baclofen
  • barbiturates (e.g., butalbital, phenobarbital)
  • benzodiazepines (e.g., lorazepam, alprazolam, diazepam)
  • buprenorphine
  • buspirone
  • chloral hydrate
  • clonidine
  • cyclobenzaprine
  • diphenoxylate
  • ketorolac
  • magnesium sulfate
  • mefloquine
  • methotrimeprazine
  • mirtazapine
  • opioids (e.g., oxycodone, hydromorphone, codeine)
  • pramipexole
  • ropinirole
  • seizure medications (e.g.,gabapentin, levetiracetam, phenytoin)
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
  • thiazolidinediones (e.g., pioglitazone, rosiglitazone)
  • tricyclic antidepressasnts (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • zolpidem
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.





 

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