Brand Name
Apo-Imipramine
Common Name
imipramine
In this drug factsheet:
DIN (Drug Identification Number)| 00360201 | APO-IMIPRAMINE 10MG TABLET |
| 00312797 | APO IMIPRAMINE 25MG TABLET |
| 00326852 | APO IMIPRAMINE 50MG TABLET |
| 00644579 | APO-IMIPRAMINE 75MG TABLET |
How does this medication work? What will it do for me?
Imipramine belongs to the class of medications called tricyclic antidepressants
(TCAs). These medications are used for the treatment of depression.
Imipramine helps improve symptoms of depression by increasing the amount of
the neurotransmitters norepinephrine and serotonin that are available in certain
parts of the brain.
Your doctor may choose to use a medication for conditions other than the ones
listed in these drug information articles. If you're unsure why you are taking
this medication, contact your doctor.
How should I use this medication?
The recommended starting dose for treatment of depression in adults is 25 mg
three times daily, with or without food. This dose is usually increased
gradually until the most effective dose is found. The maximum daily dose is
300 mg. It may take several weeks before the medication has its full effect
so you should be patient with the results. Your doctor will try to eventually
prescribe the lowest dose that is effective. Once this dose has been reached,
you may be able to take your entire dose at bedtime as recommended by your doctor.
Many things can affect the dose of medication that a person needs, such as
body weight, other medical conditions, and other medications. If your doctor
has recommended a dose different from the ones given here, do not change
the way that you are taking the medication without consulting your doctor.
It is very important that this medication be taken on a regular schedule as
prescribed by the doctor. If you miss a dose of this medication, take it as
soon as you remember it. If it is almost time for your next dose, skip the missed
dose and carry on with your regular schedule. Do not double-up on doses.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?
10 mg
Each round, light brown, biconvex, film-coated tablet, identified "10", contains imipramine HCl 10 mg. Nonmedicinal ingredients: carnauba wax, FD&C Yellow No. 6, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide and yellow ferric oxide.
25 mg
Each round, light brown, biconvex, film-coated tablet, identified "25", contains imipramine HCl 25 mg. Nonmedicinal ingredients: carnauba wax, FD&C Yellow No. 6, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide and yellow ferric oxide.
50 mg
Each round, light brown, biconvex, film-coated tablet, identified "50", contains imipramine HCl 50 mg. Nonmedicinal ingredients: carnauba wax, FD&C Yellow No. 6, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide and yellow ferric oxide.
75 mg
Each round, light brown, biconvex, film-coated tablet, scored and identified "APO" over "75", contains imipramine HCl 75 mg. Nonmedicinal ingredients: carnauba wax, FD&C Yellow No. 6, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red ferric oxide, titanium dioxide and yellow ferric oxide.
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.
Who should NOT take this medication?
Imipramine should not be used by anyone who:
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