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Drug Info > A > Apo-Doxepin
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DIN (Drug Identification Number)


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Brand Name

Apo-Doxepin

Common Name
doxepin HCl


In this drug factsheet:



DIN (Drug Identification Number)

02050048 APO-DOXEPIN 100MG CAPSULE
02049996 APO-DOXEPIN 10MG CAPSULE
02050005 APO-DOXEPIN 25MG CAPSULE
02050013 APO-DOXEPIN 50MG CAPSULE
02050021 APO-DOXEPIN 75MG CAPSULE

How does this medication work? What will it do for me?

Doxepin belongs to the family of medications known as tricyclic antidepressants. It is used to treat depression, especially when anxiety is one of the symptoms. Doxepin is also used to treat people with alcoholism who also have anxiety or depression.

Tricyclic antidepressants work by increasing the amount of norepinephrine and serotonin neurotransmitters available in certain parts of the brain.

Your doctor may have suggested this medication for conditions other than the ones listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

How should I use this medication?

The recommended adult daily dose of doxepin ranges from 75 mg to 300 mg in three divided doses. The usual starting dose is 25 mg three times daily. The total dose can be taken at bedtime once the final dose is reached. Lower doses may be used by seniors.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that this medication be taken exactly as prescribed by the doctor. If you miss a dose, take it as soon as possible and continue on with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue on with your regular dosing schedule. Do not double doses.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

10 mg
Each No. 4, pink and scarlet capsule, identified "APO 10", contains doxepin HCl equivalent to doxepin base 10 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: EEC amaranth, D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, FD&C Yellow No. 6, gelatin and titanium dioxide.

25 mg
Each No. 4, pink and blue capsule, identified "APO 25", contains doxepin HCl equivalent to doxepin base 25 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

50 mg
Each No. 2, flesh and pink capsule, identified "APO 50", contains doxepin HCl equivalent to doxepin base 50 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, FD&C Red No. 40, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

75 mg
Each No. 2, flesh - coloured capsule, identified "APO 75", contains doxepin HCl equivalent to doxepin base 75 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, gelatin, silicon dioxide, sodium lauryl sulfate and titanium dioxide.

100 mg
Each No. 1, flesh and blue capsule, identified "APO 100", contains doxepin HCl equivalent to doxepin base 100 mg. Nonmedicinal ingredients: colloidal silicon dioxide, croscarmellose sodium, lactose, microcrystalline cellulose, stearic acid and talc; capsule shell: D&C Red No. 28, D&C Yellow No. 10, edible black ink (pharmaceutical glaze, synthetic black iron oxide, FD&C Blue No. 2 aluminum lake, FD&C Red No. 40 aluminum lake, FD&C Blue No. 1 aluminum lake, D&C Yellow No. 10 aluminum lake; may contain: n-butyl alcohol, propylene glycol, SDA-3A alcohol), FD&C Blue No. 1, gelatin, sodium lauryl sulfate, silicon dioxide and titanium dioxide.

Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

Who should NOT take this medication?

Doxepin should not be taken by anyone who:

  • is allergic to doxepin or any of the ingredients of the medication or any other dibenzoxepin compounds
  • has glaucoma or increased eye pressure
  • has urinary retention
  • has just had a heart attack
  • has acute congestive heart failure
  • has blood disorders
  • has severe liver disease
  • has taken a MAO inhibitor (e.g., phenelzine, tranylcypromine) within the last 14 days
  • is a child




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