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Drug Info > M > Mefenamic
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DIN (Drug Identification Number)


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Brand Name


Common Name
mefenamic acid

In this drug factsheet:

DIN (Drug Identification Number)


How does this medication work? What will it do for me?

Mefenamic acid belongs to the class of medications called nonsteroidal anti-inflammatories (NSAIDs). It is used to relieve moderately severe pain, such as muscular aches and pains, menstrual cramps, headaches, and dental pain.

Mefenamic acid relieves pain and inflammation as long as it is being taken, however it does not correct the cause of the pain.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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How should I use this medication?

The recommended adult dose (for people more than 14 years old) is 500 mg for the first dose followed by 250 mg every six hours as needed, usually not to exceed one week of treatment. In the case of menstrual cramps, treatment is usually not necessary for longer than two or three days.

Mefenamic acid is best taken with or after food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

Each yellow and blue capsule, with "250" marked on it contains 250 mg of mefenamic acid. Nonmedicinal ingredients: stearic acid, croscarmellose sodium, sodium lauryl sulfate, colloidal silicon dioxide, microcrystalline cellulose, gelatin, FD&C Yellow No. 10, FD&C Yellow No. 6, FD&C Blue No. 1, and titanium dioxide.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to mefenamic acid or any ingredients of the medication
  • are breast-feeding
  • are in the third trimester of pregnancy (after 28 weeks of pregnancy)
  • are less than 18 years old
  • have active stomach bleeding such as gastric or duodenal ulcers
  • have a history of asthma, itchy skin rash, or allergic reactions after taking ASA (acetylsalicylic acid) or other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, celecoxib, diclofenac, indomethacin, etc.)
  • have bleeding in the brain
  • have or recently had an inflammatory condition of the stomach and intestines such ulcerative colitis
  • have recently had heart bypass surgery
  • have severe or active kidney disease
  • have severe or active liver disease
  • have severe, uncontrolled heart failure
  • have too much potassium in the body (hyperkalemia)



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