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Drug Info > M > Mylan-Fluconazole
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Brand Name
Mylan-Fluconazole

Common Name
fluconazole


In this drug factsheet:



What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • diarrhea
  • headache
  • nausea
  • skin rash
  • stomach pain
  • vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • fever and chills
  • loss of appetite
  • signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, cuts that don't stop bleeding)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • skin rash or itching

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • seizures
  • signs of a severe allergic reaction (hives; difficulty breathing; swelling of the face, tongue, or throat)
  • symptoms of a severe skin rash (such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergies: Caution should be used by those taking fluconazole who are allergic to other "azoles" such as ketoconazole or itraconazole. If you develop symptoms of an allergic reaction, such as skin rash, hives, difficulty breathing; swelling of the face, tongue, or throat, seek immediate medical attention.

Kidney function: People with kidney disease or reduced kidney function should discuss with their doctor how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver damage: In rare cases, this medication may cause liver damage in people with serious medical conditions. Your doctor may monitor you with regular blood tests to check for side effects while you are taking fluconazole. If you notice signs of liver damage such as abdominal pain, yellowing of the skin or eyes, dark or amber urine, or pale stools, contact your doctor right away.

QT prolongation: In rare cases, this medication can affect the electrical activity of the heart and cause a condition known as QT prolongation. Your doctor will monitor your heart rhythm regularly while you are taking this medication with a test called an electrocardiogram (ECG). You should not take this medication if your ECG already shows that you have QT prolongation or if you are taking a medication that can cause QT prolongation.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately. Women who take fluconazole for vaginal yeast infections and who may become pregnant should consider using adequate birth control.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking fluconazole, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: This medication has been shown to be safe and effective for children over 6 months of age.





What other drugs could interact with this medication?

There may be an interaction between fluconazole and any of the following:

  • alfentanil
  • anti-HIV medications (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • astemizole
  • benzodiazepines (e.g., alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, flurazepam, midazolam)
  • birth control pills
  • buspirone
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, nisoldipine, verapamil)
  • cimetidine
  • cisapride
  • clopidogrel
  • colchicines
  • cyclosporine
  • dapsone
  • diabetes medications (e.g., glyburide, tolbutamide)
  • didanosine
  • fosphenytoin
  • haloperidol
  • hydrochlorothiazide
  • ifosfamide
  • indapamide
  • irinotecan
  • losartan
  • macrolide antiobiotics (e.g., azithromycin, clarithromycin, erythromycin)
  • moclobemide
  • montelukast
  • paclitaxel
  • phenytoin
  • pimozide
  • procainamide
  • propafenone
  • quetiapine
  • quinidine
  • quinine
  • quinolone antibiotics (e.g., levofloxacin, norfloxacin, moxifloxacin)
  • rifabutin
  • rifampin
  • risperidone
  • sildenafil
  • sirolimus
  • SSRIs (e.g., fluoxetine, citalopram, escitalopram,
  • "statin" cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • sulfonamide antibiotics (e.g., sulfadiazine, sulfamethoxazole)
  • tacrolimus
  • tadalafil
  • tamoxifen
  • temsirolimus
  • terfenadine
  • theophylline
  • thioridazine
  • tolterodine
  • tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
  • vardenafil
  • vinblastine
  • vincristine
  • voriconazole
  • warfarin
  • zidovudine
  • zolpidem
  • zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, decongestants, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.





 

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