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Drug Info > S > Supeudol
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In this drug factsheet:

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • dizziness, lightheadedness, or feeling faint
  • drowsiness
  • dry mouth
  • headache
  • lack of energy or tiredness
  • nausea or vomiting
  • sweating

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • depression or other mood or mental changes
  • fast, slow, or pounding heartbeat
  • feelings of unreality
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • itching
  • redness or flushing of face
  • skin rash
  • trembling or uncontrolled muscle movements
  • unusual excitement or restlessness

Stop taking the medication and seek immediate medical attention if any of the following symptoms of overdose occur:

  • chest tightness or wheezing
  • cold, clammy skin
  • confusion
  • convulsions (seizures)
  • fainting
  • pinpoint-sized pupils
  • severe drowsiness
  • signs of a severe allergic reaction (hives; difficulty breathing; swelling of the face, throat, or tongue)
  • slow heartbeat
  • slow or troubled breathing

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Alcohol: Do not consume alcohol while taking this medication, as this may lead to dangerous side effects.

Constipation: Constipation happens frequently while taking opioid (narcotic) pain relievers on a regular basis. Your doctor will discuss the use of stimulant laxatives, stool softeners, and other measures to be used as required.

Controlled-release: Controlled-release forms of this medication are designed to work over 12 hours when swallowed whole. If a tablet is broken, cut, crushed, dissolved, or chewed, the entire 12-hour dose will be absorbed rapidly into your body. This can be very dangerous, causing serious problems such as slowed breathing and overdose, which can be fatal.

Dependence: As with other opioid medications (narcotics), this medication may become habit-forming if taken for long periods of time. Misuse of oxycodone usually is not a problem when it is used appropriately for pain relief.

Withdrawal symptoms (e.g., body aches, diarrhea, nausea, nervousness, restlessness, runny nose, sneezing, goose bumps, shaking, shivering, nausea, stomach cramps, fast heart rate, fever, sweating) may occur if oxycodone is stopped suddenly. If you have been taking this medication for a long time and no longer require it for pain control, you should stop the medication gradually as directed by their doctor.

Difficulty breathing: Oxycodone can cause serious breathing problems. If you experience slowed breathing or difficulty breathing, seek immediate medical attention. If you have lung problems, head injury, and are taking other medications that can slow breathing, you are more at risk for experiencing this. Make sure you follow the instructions on how to properly use this medication. If you have any questions, contact your doctor or pharmacist.

Difficulty swallowing: There have been reports of choking and difficulty swallowing the controlled-release form of oxycodone. To avoid difficulty swallowing, take only one tablet at a time and take the controlled-release tablet with enough water so that you are able to completely swallow the tablet immediately after placing it in your mouth.

Do not lick, pre-soak, or wet the tablet before you place it in your mouth. If you experience difficulty swallowing or pain after taking controlled-release oxycodone, contact your doctor immediately.

Drowsiness/reduced alertness: Oxycodone may impair the mental or physical abilities needed for activities such as driving or operating machinery. Do not drive or perform other potentially hazardous tasks if this mediation affects your ability to do these safely.

Kidney function: If you have severely reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: If you have severely reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Medical conditions: If you have abnormal heart rhythms, reduced adrenal function (e.g., Addison's disease), low thyroid, inflammation of the pancreas, enlarged prostate, or urethral strictures, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Stopping the medication: Do not suddenly stop taking this medication since withdrawal symptoms may occur. These symptoms include body aches, diarrhea, nausea, nervousness, restlessness, runny nose, sneezing, goose bumps, shaking, shivering, nausea, stomach cramps, fast heart rate, fever, and sweating. Your doctor will advise you on how to safely stop taking this medication if you no longer require it for pain control.

Tolerance: Oxycodone may lead to tolerance when used for long periods of time. Tolerance means that your body gets used to the medication so that more medication may be needed to produce the same pain relief. Your doctor will recommend the dose of oxycodone that is most appropriate for you. Do not change your dose or the way you are using this medication on your own. Speak to your doctor if you have any questions.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if oxycodone passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding. This medication is not recommended for breast-feeding women.

Children: The safety and effectiveness of using this mediation have not been established for children.

Seniors: Seniors may be more sensitive to the effects of this medication.

What other drugs could interact with this medication?

There may be an interaction between oxycodone and any of the following:

  • alcohol
  • anaesthetics
  • antihistamines that cause drowsiness (e.g., diphenhydramine)
  • barbiturates (e.g., secobarbital, phenobarbital)
  • benzodiazepines (e.g., diazepam, lorazepam)
  • beta-blockers (e.g., metoprolol, propranolol)
  • chloral hydrate
  • cimetidine
  • clarithromycin
  • glutethimide
  • imatinib
  • itraconazole
  • ketoconazole
  • MAO inhibitors (e.g., phenelzine, tranylcypromine)
  • nefazodone
  • other medications that cause drowsiness
  • other opioids (e.g., morphine, codeine)
  • phenothiazines (e.g., chlorpromazine)
  • protease inhibitors (e.g., saquinavir, ritonavir, indinavir, amprenavir, atazanavir, lopinavir
  • quinidine
  • tricyclic antidepressants (e.g., amitriptyline, desipramine)
  • voriconazole

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.



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