In this drug factsheet:DIN (Drug Identification Number)
|01984845 ||BONEFOS 400MG CAPSULE|
|01984837 ||BONEFOS 60MG/ML AMPOULE|
How does this medication work? What will it do for me?
Clodronate belongs to a family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) for people who have cancer. Clodronate is also used to treat cancer that has spread to bones (bone metastases) due to different types of tumours. Clodronate works by reducing the breakdown of bone.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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How should I use this medication?
To treat hypercalcemia (high blood calcium) for people who have cancer, clodronate is started with an intravenous infusion (injection into the vein), and then switched to oral (by mouth) maintenance treatment.
The recommended adult dose of the intravenous infusion is 300 mg daily. Following intravenous treatment, oral treatment is started at a recommended dose of 1,600 mg to 2,400 mg daily given as a single daily dose or as 2 divided doses. The maximum recommended daily dose is 3,200 mg.
To treat cancer that has spread to bones (bone metastases) due to different types of tumours, the recommended initial dose is 1,600 mg daily given orally (by mouth). If needed, this dose may be increased by your doctor. The maximum daily dose is 3,200 mg.
Clodronate capsules should be taken on an empty stomach with a glass of plain water, at least 2 hours before or after food.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each mL of the intravenous solution for infusion contains clodronate tetrahydrate, corresponding to 60 mg of anhydrous clodronate. Nonmedicinal ingredients: sodium hydroxide (to adjust the pH) and water for injection.
Each yellow, hard gelatin capsule contains 400 mg of anhydrous clodronate (as the tetrahydrate). Nonmedicinal ingredients: calcium stearate, colloidal anhydrous silica, gelatin, iron oxide (red and yellow), lactose, talc, and titanium dioxide.
Who should NOT take this medication?
Do not use this medication if you:
- are allergic to clodronate or any ingredients of this medication
- are allergic to other bisphosphonates (e.g., alendronate, etidronate, risedronate)
- are pregnant or breast-feeding
- are taking other bisphosphonate medications (e.g., alendronate, etidronate, risedronate)
- have reduced kidney function
- have severe inflammation of the gastrointestinal tract