zoledronic acid for injection
In this drug factsheet:DIN (Drug Identification Number)
|02248296 ||ZOMETA 4MG/5ML CONCENTRATE FOR INJECTION|
How does this medication work? What will it do for me?
Zoledronic acid belongs to the family of medications known as bisphosphonates. It is used to treat hypercalcemia (high blood calcium) for people who have cancer. Zoledronic acid is also used to prevent or delay complications (e.g., bone fractures or bone pain requiring surgery or radiotherapy) due to cancer that has spread to bones (bone metastases) from different types of tumours and multiple myeloma (cancer of the bone marrow).
This medication works by slowing the rate of bone change and may prevent bone breakdown and uncontrolled bone growth caused by cancer that has spread to the bone.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop receiving this medication without consulting your doctor.
How should I use this medication?
The dosage of this medication depends on the condition that is being treated.
For tumour-induced hypercalcemia (high calcium levels in the blood), the recommended starting dose of zoledronic acid for hypercalcemia is 4 mg given as a single intravenous injection (into the vein) over no less than 15 minutes. This dose may be repeated after at least 1 week for people who do not respond completely to this dose or whose calcium level does not remain normal.
For bone metastases and multiple myeloma, the recommended dose of zoledronic acid for bone metastases is 4 mg given as a single intravenous injection (into the vein) over no less than 15 minutes every 3 to 4 weeks. For people receiving chemotherapy, zoledronic acid may be given either before or after treatment. It is important to take a calcium supplement of 500 mg by mouth and a multivitamin containing at least 400 IU of vitamin D daily, unless high blood calcium levels develop. If this occurs, calcium and vitamin D supplements should be discontinued as advised by your doctor. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.
It is important this medication be given exactly as recommended by your doctor. If you miss an appointment to receive zoledronic acid, contact your doctor as soon as possible to reschedule your appointment.
This medication is stored at room temperature. After mixing, it is stored in the refrigerator. Keep this medication out of the sight and reach of children and pets.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each 5 mL vial of concentrated sterile liquid for intravenous (IV) injection contains 4 mg of zoledronic acid, corresponding to 4.264 mg of zoledronic acid monohydrate. Nonmedicinal ingredients: mannitol, sodium citrate, and water for injection.
Who should NOT take this medication?
Do not take zoledronic acid if you:
- are allergic to zoledronic acid, or any ingredients of this medication
- are allergic to other bisphosphonates (e.g., alendronate, etidronate, risedronate)
- have low levels of calcium in the blood at the time this medication is given
- are breast-feeding
- are pregnant