latanoprost - timolol
In this drug factsheet:DIN (Drug Identification Number)
|02246619 ||XALACOM OPHTHALMIC SOLUTION|
How does this medication work? What will it do for me?
This is a combination product containing two different medications: latanoprost and timolol. Latanoprost belongs to a class of medications called prostaglandin analogs. It works to reduce the pressure in the eye by allowing fluid in the eye to flow better. Timolol belongs to a class of medications called beta-adrenergic receptor blockers (also known as "beta-blockers"). Latanoprost - timolol solution is available in an eye-drop form. It is used to reduce the pressure inside the eye for people with open-angle glaucoma or intraocular hypertension (increased pressure in the eye).
This medication is intended to be used by people with chronic open-angle glaucoma or by people with ocular hypertension who do not get a complete response to treatment with only one medication and are considered appropriate candidates for combination therapy. The combined effect of these two medications results in a larger decrease in pressure compared to either medication alone. However, this medication is not to be used as initial treatment.
Fluid is constantly being formed and drained out of the eye. When this fluid does not drain out of the eye properly, pressure inside the eye increases. Latanoprost - timolol works by reducing the amount of fluid produced by the eye and by increasing the flow of fluid out of the eye.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.
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How should I use this medication?
The recommended dose of latanoprost - timolol is one drop to the affected eye(s) once daily.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
To use the eye drops:
- Wash your hands before using the eye drops.
- Remove the cap and place it in a clean location. To avoid possible contamination, keep the tip of the container away from contact with any surface.
- Tilt the head back and look towards the ceiling.
- With your index finger, gently pull the lower eyelid down and away from the eye to form a pouch.
- Apply one drop into the pouch but do not allow the tip of the container to touch the eye or areas around the eye.
- Gently apply pressure to the inner corner of the eye (at the bridge of the nose) for about 30 seconds (this is called nasolacrimal occlusion). This prevents the medication from dripping down through the tear duct and entering the bloodstream, which could cause you to experience some side effects.
- Repeat with the other eye, if prescribed by your physician.
- Wash your hands again to remove any medication.
Do not allow the dropper tip of the bottle to touch the eye or other surrounding structures. This can contaminate the tip with common bacteria known to cause eye infections. Serious damage to the eye, possibly leading to loss of vision may result if you use eye drop solutions that have become contaminated.
If you use other eye drops as well, wait at least 5 minutes before using them.
If you wear contact lenses, remove them before instilling latanoprost - timolol into your eye. You may put your contact lenses back in 15 minutes after using the medication.
It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular schedule. Do not instill a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store unopened containers of eye drops in the refrigerator (2°C to 8°C), out of direct light. Once the bottle has been opened, keep the eye drops at room temperature up to 25°C and away from light. Keep this medication out of the reach of children. Latanoprost - timolol eye drops must be used within 10 weeks after opening the container.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Each 1 mL of sterile, clear, colourless aqueous solution contains latanoprost 50 µg and timolol 5 mg. Each drop approximately contains latanoprost 1.5 µg and timolol 150 µg. Nonmedicinal ingredients: sodium chloride, sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate anhydrous, water for injection, and benzalkonium chloride. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH (acidity).
Who should NOT take this medication?
Latanoprost - timolol eye drops should not be used by anyone who:
- is allergic to latanoprost, timolol, benzalkonium chloride, or to any ingredients of the medication
- has asthma or has had asthma in the past
- has certain heart diseases or conditions:
- cardiogenic shock (heart cannot provide enough oxygen to the body)
- second-degree or third-degree atrioventricular (AV) block (electrical problems)
- sinus bradycardia (slow heartbeat)
- uncontrolled heart failure (heart cannot pump effectively)
- has severe chronic obstructive pulmonary disease (COPD; e.g., emphysema, chronic bronchitis)