atovaquone - proguanil
In this drug factsheet:DIN (Drug Identification Number)
|02264935 ||MALARONE PEDIATRIC 62.5MG TABLET|
|02238151 ||MALARONE 250MG TABLET|
How does this medication work? What will it do for me?
This combination medication contains two active ingredients: atovaquone and proguanil. It is used to treat and prevent malaria. It works by killing P. falciparum, the parasite that causes malaria. It may be effective in areas where other antimalarial medications are no longer effective.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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How should I use this medication?
The usual recommended adult dose for preventing malaria is 1 tablet daily, starting 1 to 2 days before entering an area where malaria is present and continuing until 7 days after leaving the affected area.
The usual recommended adult dose for treating malaria is 4 tablets once daily for 3 days.
Children's doses for malaria prevention and treatment are based on body weight.
This medication should be swallowed whole with fluid; however, it may be crushed and mixed in condensed milk immediately before taking the dose if it cannot be swallowed whole.
This medication should be taken with food or a milky drink at the same time each day. If vomiting occurs within one hour of the dose, another dose should be taken. If vomiting continues, your doctor will likely consider using another treatment.
People who are unable to eat food should use a different treatment if possible, as the absorption of the medication is significantly reduced when the stomach is empty.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
What form(s) does this medication come in?
Malarone 250 mg tablet
Each pink, round, biconvex, film-coated tablet, branded "GX CM3", contains atovaquone 250 mg and proguanil HCl 100 mg (equivalent to proguanil base 87.4 mg). Nonmedicinal ingredients: low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, poloxamer 188, povidone K30, and sodium starch glycolate; coating: hypromellose, macrogol 400, polyethylene glycol 8000, red iron oxide, and titanium dioxide.
Malarone Pediatric 62.5 mg tablet
Each pink, round, biconvex, film-coated tablet, branded "GX CG7", contains atovaquone 62.5 mg and proguanil HCl 25 mg (equivalent to proguanil base 21.86 mg). Nonmedicinal ingredients: low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose, poloxamer 188, povidone K30, and sodium starch glycolate; coating: hypromellose, macrogol 400, polyethylene glycol 8000, red iron oxide, and titanium dioxide.
Malarone Pediatric Tablets are smaller in size than Malarone Tablets (adult strength).
Who should NOT take this medication?
Do not take this medication if you:
- are allergic to atovaquone, proguanil, or any ingredients of the medication
- have severe kidney impairment