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Drug Info > T > Tylenol No. 4 with Codeine
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DIN (Drug Identification Number)


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Brand Name

Tylenol No. 4 with Codeine

Common Name
acetaminophen - codeine


In this drug factsheet:



DIN (Drug Identification Number)

02163918 TYLENOL NO. 4 WITH CODEINE TABLET

How does this medication work? What will it do for me?

This combination product contains two medications: acetaminophen and codeine. Acetaminophen belongs to the group of medications called analgesics (pain relievers) and antipyretics (fever reducers). Codeine belongs to the family of medications known as opioid analgesics (narcotic pain relievers). This medication is used to relieve moderate to severe pain.

Codeine works by acting on the central nervous system to block pain signals, increasing the ability to tolerate pain. Acetaminophen works by raising your pain threshold.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

Acetaminophen with codeine comes in a variety of different strengths and dosage forms. Dosing depends on the strength and dosage form being used.

Tablets: The recommended adult dose is 1 tablet every 4 to 6 hours as needed for pain. No more than 6 tablets should be taken in a 24 hour period.

Liquid: The recommended adult dose is 10 mL to 20 mL every 4 hours as needed for pain. No more than 5 doses should be taken in a 24 hour period. For children, the recommended dose is based on body weight and is given every 4 hours as needed for pain.

Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The dose limits for the single and 24-hour dose, as well as the time interval between doses, should be followed strictly as recommended by your doctor. This medication may be habit-forming if taken for long periods of time. If you have been taking this medication for a long period of time, do not stop taking this medication without talking with your doctor. If this medication is stopped suddenly, you may experience withdrawal symptoms such as anxiety, sweating, trouble sleeping, shakiness, nausea, tremors, diarrhea, or hallucinations. If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects.

It is important to take this medication exactly as prescribed by your doctor.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.





What form(s) does this medication come in?

Each round, hard, white tablet, flat-faced, bevelled, engraved with "4" on one side and flat-faced special design, bevelled, engraved with "McNEIL" on the other side, contains acetaminophen 300 mg and codeine phosphate 60 mg. Nonmedicinal ingredients: cellulose, cornstarch, magnesium stearate, sodium lauryl sulfate, sodium starch glycolate, and talc. This medication does not contain gluten, lactose, sodium metabisulfite, or tartrazine.

Who should NOT take this medication?

Do not take this medication if you are:

  • allergic to acetaminophen, codeine, or any ingredients of the medication
  • 12 years of age or younger


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